Analysis of a deterministic-stochastic oncolytic M1 model involving immune response via crossover behaviour: ergodic stationary distribution and extinction
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Atangana, Abdon
[1
,2
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Rashid, Saima
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Govt Coll Univ, Dept Math, Faislabad, PakistanUniv Free State, Inst Groundwater Studies, Fac Nat & Agr Sci, ZA-9300 Bloemfontein, South Africa
Rashid, Saima
[3
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[1] Univ Free State, Inst Groundwater Studies, Fac Nat & Agr Sci, ZA-9300 Bloemfontein, South Africa
[2] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung, Taiwan
Oncolytic virotherapy is a viable chemotherapeutic agent that identifies and kills tumor cells using replication-competent pathogens. Oncolytic alphavirus M1 is a naturally existing disease that has been shown to have rising specificity and potency in cancer progression. The objective of this research is to introduce and analyze an oncolytic M1 virotherapy framework with spatial variability and anti-tumor immune function via piecewise fractional differential operator techniques. To begin, we potentially demonstrate that the stochastic system's solution is non-negative and global by formulating innovative stochastic Lyapunov candidates. Then, we derive the existence-uniqueness of an ergodic stationary distribution of the stochastic framework and we establish a sufficient assumption RP0 < 1 extermination of tumor cells and oncolytic M1 virus. Using meticulous interpretation, this model allows us to analyze and anticipate the procedure from the start to the end of the tumor because it allows us to examine a variety of behaviours ranging from crossover to random mechanisms. Furthermore, the piecewise differential operators, which can be assembled with operators including classical, Caputo, Caputo-Fabrizio, Atangana-Baleanu, and stochastic derivative, have decided to open up innovative avenues for readers in various domains, allowing them to encapsulate distinct characteristics in multiple time intervals. Consequently, by applying these operators to serious challenges, scientists can accomplish better outcomes in documenting facts.
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King Abdulaxix Univ, Fac Sci, Dept Math, POB 80203, Jeddah 21589, Saudi ArabiaKing Abdulaxix Univ, Fac Sci, Dept Math, POB 80203, Jeddah 21589, Saudi Arabia
Elaiw, A. M.
Al Agha, A. D.
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King Abdulaxix Univ, Fac Sci, Dept Math, POB 80203, Jeddah 21589, Saudi ArabiaKing Abdulaxix Univ, Fac Sci, Dept Math, POB 80203, Jeddah 21589, Saudi Arabia
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Hassan II Univ Casablanca, Fac Sci Ben Msik, Lab Anal Modeling & Simulat LAMS, POB 7955 Sidi Othman, Casablanca, MoroccoHassan II Univ Casablanca, Fac Sci Ben Msik, Lab Anal Modeling & Simulat LAMS, POB 7955 Sidi Othman, Casablanca, Morocco
El Younoussi, Majda
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Hajhouji, Zakaria
Hattaf, Khalid
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Hassan II Univ Casablanca, Fac Sci Ben Msik, Lab Anal Modeling & Simulat LAMS, POB 7955 Sidi Othman, Casablanca, Morocco
Ctr Reg Metiers Educ & Format CRMEF, Equipe Rech Modelisat & Enseignement Math ERMEM, Casablanca 20340, MoroccoHassan II Univ Casablanca, Fac Sci Ben Msik, Lab Anal Modeling & Simulat LAMS, POB 7955 Sidi Othman, Casablanca, Morocco