Analysis of a deterministic-stochastic oncolytic M1 model involving immune response via crossover behaviour: ergodic stationary distribution and extinction

被引:5
|
作者
Atangana, Abdon [1 ,2 ]
Rashid, Saima [3 ]
机构
[1] Univ Free State, Inst Groundwater Studies, Fac Nat & Agr Sci, ZA-9300 Bloemfontein, South Africa
[2] China Med Univ, China Med Univ Hosp, Dept Med Res, Taichung, Taiwan
[3] Govt Coll Univ, Dept Math, Faislabad, Pakistan
来源
AIMS MATHEMATICS | 2023年 / 8卷 / 02期
关键词
oncolytic M1 model; fractional derivatives; Stochastic-deterministic models; numerical solutions; Ito?derivative; chaotic attractors; MATHEMATICAL-MODEL; GLOBAL PROPERTIES; VIRUS; VIROTHERAPY; DYNAMICS; EFFICACY; THERAPY;
D O I
10.3934/math.2023167
中图分类号
O29 [应用数学];
学科分类号
070104 ;
摘要
Oncolytic virotherapy is a viable chemotherapeutic agent that identifies and kills tumor cells using replication-competent pathogens. Oncolytic alphavirus M1 is a naturally existing disease that has been shown to have rising specificity and potency in cancer progression. The objective of this research is to introduce and analyze an oncolytic M1 virotherapy framework with spatial variability and anti-tumor immune function via piecewise fractional differential operator techniques. To begin, we potentially demonstrate that the stochastic system's solution is non-negative and global by formulating innovative stochastic Lyapunov candidates. Then, we derive the existence-uniqueness of an ergodic stationary distribution of the stochastic framework and we establish a sufficient assumption RP0 < 1 extermination of tumor cells and oncolytic M1 virus. Using meticulous interpretation, this model allows us to analyze and anticipate the procedure from the start to the end of the tumor because it allows us to examine a variety of behaviours ranging from crossover to random mechanisms. Furthermore, the piecewise differential operators, which can be assembled with operators including classical, Caputo, Caputo-Fabrizio, Atangana-Baleanu, and stochastic derivative, have decided to open up innovative avenues for readers in various domains, allowing them to encapsulate distinct characteristics in multiple time intervals. Consequently, by applying these operators to serious challenges, scientists can accomplish better outcomes in documenting facts.
引用
收藏
页码:3236 / 3268
页数:33
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