Disentangling the relationship of subjective cognitive decline and depressive symptoms in the development of cognitive decline and dementia

被引：6

作者：

Kleineidam, Luca ^{[1
,2
]}

Wagner, Michael ^{[1
,2
]}

Guski, Jannis ^{[1
]}

Wolfsgruber, Steffen ^{[2
]}

Miebach, Lisa ^{[1
,2
]}

Bickel, Horst ^{[3
]}

Koenig, Hans-Helmut ^{[4
]}

Weyerer, Siegfried ^{[5
]}

Luehmann, Dagmar ^{[6
]}

Kaduszkiewicz, Hanna ^{[6
,7
]}

Luppa, Melanie ^{[8
]}

Rohr, Susanne ^{[8
]}

Pentzek, Michael ^{[9
]}

Wiese, Birgitt ^{[10
]}

Maier, Wolfgang ^{[1
]}

Scherer, Martin ^{[6
]}

Kornhuber, Johannes ^{[11
,12
]}

Peters, Oliver ^{[13
,14
]}

Frolich, Lutz ^{[15
]}

Wiltfang, Jens ^{[16
,17
,18
]}

Lewczuk, Piotr ^{[11
,12
,19
,20
]}

Huell, Michael ^{[21
,22
]}

Ramirez, Alfredo ^{[1
,2
,23
,24
,25
,26
]}

Jessen, Frank ^{[2
,24
,27
]}

Riedel-Heller, Steffi G. ^{[8
]}

Heser, Kathrin ^{[1
]}

机构：

[1] Univ Hosp Bonn, Dept Neurodegenerat Dis & Geriatr Psychiat, Venusberg Campus 1, D-53127 Bonn, Germany

[2] German Ctr Neurodegenerat Dis DZNE, Bonn, Germany

[3] Tech Univ Munich, Dept Psychiat, Klinikum Rechts Isar, Munich, Germany

[4] Univ Med Ctr Hamburg Eppendorf, Hamburg Ctr Hlth Econ, Dept Hlth Econ & Hlth Serv Res, Hamburg, Germany

[5] Mannheim Heidelberg Univ, Med Fac, Cent Inst Mental Hlth, Heidelberg, Germany

[6] Univ Med Ctr Hamburg Eppendorf, Ctr Psychosocial Med, Dept Primary Med Care, Hamburg, Germany

[7] Univ Kiel, Med Fac, Inst Gen Practice, Kiel, Germany

[8] Univ Leipzig, Inst Social Med Occupat Hlth & Publ Hlth ISAP, Leipzig, Germany

[9] Heinrich Heine Univ, Med Fac, Ctr Hlth & Soc Chs, Inst Gen Practice Ifam, Dusseldorf, Germany

[10] Hannover Med Sch, Ctr Informat Management, Hannover, Germany

[11] Univ Klinikum Erlangen, Dept Psychiat & Psychotherapy, Erlangen, Germany

[12] Friedrich Alexander Univ Erlangen Nurnberg, Erlangen, Germany

[13] Charite Univ Med Berlin, Dept Psychiat, Berlin, Germany

[14] German Ctr Neurodegenerat Dis, DZNE, Berlin, Germany

[15] Heidelberg Univ, Med Fac Mannheim, Cent Inst Mental Hlth, Dept Geriatr Psychiat, Mannheim, Germany

[16] Univ Med Ctr Gottingen, Dept Psychiat & Psychotherapy, Gottingen, Germany

[17] German Ctr Neurodegenerat Dis DZNE, Gottingen, Germany

[18] Univ Aveiro, Inst Biomed iBiM, Dept Med Sci, Neurosci & Signaling Grp, Aveiro, Portugal

[19] Med Univ Bialystok, Dept Neurodegenerat Diagnost, Bialystok, Poland

[20] Univ Hosp Bialystok, Dept Biochem Diagnost, Bialystok, Poland

[21] Univ Freiburg, Dept Psychiat & Psychotherapy, Emmendingen, Germany

[22] Clin Geriatr Psychiat & Psychotherapy, Emmendingen, Germany

[23] Univ Cologne, Med Fac, Dept Psychiat & Psychotherapy, Div Neurogenet & Mol Psychiat, Cologne, Germany

[24] Univ Cologne, Excellence Cluster Cellular Stress Responses Agin, Cologne, Germany

[25] Dept Psychiat, San Antonio, TX USA

[26] Glenn Biggs Inst Alzheimers & Neurodegenerat Dis, San Antonio, TX USA

[27] Univ Cologne, Med Fac, Dept Psychiat & Psychotherapy, Cologne, Germany

来源：

ALZHEIMERS & DEMENTIA | 2023年 / 19卷 / 05期

关键词：

Alzheimer's disease; depression; latent difference score model; subjective cognitive decline; temporal sequence; NEUROPSYCHOLOGICAL ASSESSMENT BATTERY; MEMORY COMPLAINTS; OLDER-PEOPLE; IMPAIRMENT; ASSOCIATIONS; PERFORMANCE; IMPROVES; RISK; PROGRESSION; ACCURACY;

D O I：

10.1002/alz.12785

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Subjective cognitive decline (SCD) and depressive symptoms (DS) frequently co-occur prior to dementia. However, the temporal sequence of their emergence and their combined prognostic value for cognitive decline and dementia is unclear. Methods Temporal relationships of SCD, DS and memory decline were examined by latent difference score modeling in a high-aged, population-based cohort (N = 3217) and validated using Cox-regression of dementia-conversion. In 334 cognitively unimpaired SCD-patients from memory-clinics, we examined the association of DS with cognitive decline and with cerebrospinal fluid (CSF) Alzheimer's disease (AD) biomarkers. Results In the population-based cohort, SCD preceded DS. High DS were associated with increased risk of dementia conversion in individuals with SCD. In SCD-patients from memory-clinics, high DS were associated with greater cognitive decline. CSF Ass42 predicted increasing DS. Discussion SCD typically precedes DS in the evolution to dementia. SCD-patients from memory-clinics with DS may constitute a high-risk group for cognitive decline. Highlights Subjective cognitive decline (SCD) precedes depressive symptoms (DS) as memory declines. Emerging or persistent DS after SCD reports predict dementia. In SCD patients, more amyloid pathology relates to increasing DS. SCD patients with DS are at high risk for symptomatic progression.

引用

页码：2056 / 2068

页数：13

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