lncRNA GPRC5D-AS1 as a ceRNA inhibits skeletal muscle aging by regulating miR-520d-5p

被引：0
|
作者：
Yu, Miao [1 ]
He, Xiuting [1 ]
Liu, Ting [1 ]
Li, Jie [1 ]
机构：
[1] First Hosp Jilin Univ, Dept Geriatr & Special Med Treatment, Changchun 130021, Peoples R China
来源：
AGING-US | 2023年 / 15卷 / 23期
关键词：
long non-coding RNA; miR-520d-5p; skeletal muscle aging; GPRC5D-AS1; competing endogenous RNA; LONG-NONCODING RNA; MYOD; DIFFERENTIATION; SARCOPENIA; SENESCENCE; CARCINOMA; ARREST; GROWTH; ROLES;
D O I：
暂无
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Sarcopenia induced by muscle aging is associated with negative outcomes in a variety of diseases. Long non coding RNAs are a class of RNAs longer than 200 nucleotides with lower protein coding potential. An increasing number of studies have shown that lncRNAs play a vital role in skeletal muscle development. According to our previous research, lncRNA GPRC5D-AS1 is selected in the present study as the target gene to further study its effect on skeletal muscle aging in a dexamethasone-induced human muscle atrophy cell model. As a result, GPRC5D-AS1 functions as a ceRNA of miR-520d-5p to repress cell apoptosis and regulate the expression of muscle regulatory factors, including MyoD, MyoG, Mef2c and Myf5, thus accelerating myoblast proliferation and differentiation, facilitating development of skeletal muscle. In conclusion, lncRNA GPRC5D-AS1 could be a novel therapeutic target for treating sarcopenia.
引用
收藏
页码：13980 / 13997
页数：18
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