Phylogenetic and genotypic characteristics of the foot-and-mouth disease virus from outbreaks in southern Vietnam, 2019

被引：1

作者：

Nguyen, Ngoc Hai ^{[1
]}

Nguyen, Trung Quan ^{[2
]}

Lai, Danh Cong ^{[1
]}

Thi, My Duyen Nguyen ^{[1
]}

Nguyen, Minh Nam ^{[3
,4
,5
,6
]}

机构：

[1] Nong Lam Univ HCMC, Fac Anim Husb & Vet Med, Dept Infect Dis & Vet Publ Hlth, Ho Chi Minh City, Vietnam

[2] P&Y Livestock Serv Co Ltd, Ho Chi Minh City, Vietnam

[3] Vietnam Natl Univ Ho Chi Minh City VNU HCM, Sch Med, Dept Biomed Engn, Ho Chi Minh City 700000, Vietnam

[4] Natl Univ HCMC, Res Ctr Genet & Reprod Hlth CGRH, Sch Med, Ho Chi Minh City, Vietnam

[5] Vietnam Natl Univ Ho Chi Minh City VNU HCM, Ho Chi Minh City 700000, Vietnam

[6] Vietnam Natl Univ Ho Chi Minh City, Sch Med, Ho Chi Minh City, Vietnam

来源：

VIROLOGY | 2023年 / 582卷

关键词：

FMDV; Vaccine; VP1; Genetic characteristics; T-CELL EPITOPE; SEROTYPE O; IDENTIFICATION; STRAIN; IMMUNODOMINANT; PROTECTION; AFRICA; EAST; ASIA; VP1;

D O I：

10.1016/j.virol.2023.03.010

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

In 2019, multiple FMD outbreaks occurred in swine farms vaccinated against FMDV in southern Vietnam. This study investigated the genotypic characteristics of FMDV strains from these outbreaks. Seven samples were collected from pigs exhibiting FMD clinical signs. All FMDV-positive samples were amplified and sequenced for the gene encoding the VP1. Results were analyzed and compared with sequences of reference strains and vaccine strains on GenBank. Phylogenetic analysis showed that all seven field isolates belonged to serotype O, topotype SEA/Mya-98. These strains shared high homology with strains from Vietnam (2018), Korea, and China, but low homology with vaccine strains. Moreover, 21 amino acid substitutions were found in the VP1 protein of the FMDV field strains, many of which were crucial antigenic determinants involved in the neutralization of FMDV. These findings suggest that the current vaccine may not be effective against the emerging FMDV strains in southern Vietnam.

引用

页码：43 / 47

页数：5

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