Double-edged sword of JAK/STAT signaling pathway in viral infections: novel insights into virotherapy

被引:13
|
作者
Mahjoor, Mohamad [1 ,2 ]
Mahmoudvand, Golnaz [3 ]
Farokhi, Simin [3 ]
Shadab, Alireza [4 ,5 ]
Kashfi, Mojtaba [1 ,6 ,7 ]
Afkhami, Hamed [1 ,6 ,8 ]
机构
[1] Qom Univ Med Sci, Cellular & Mol Res Ctr, Qom, Iran
[2] Iran Univ Med Sci, Fac Med, Dept Immunol, Tehran, Iran
[3] Lorestan Univ Med Sci, Student Res Comm, USERN Off, Khorramabad, Iran
[4] Semnan Univ Med Sci, Sch Med, Dept Immunol, Semnan, Iran
[5] Iran Univ Med Sci, Deputy Hlth, Tehran, Iran
[6] Semnan Univ Med Sci, Nervous Syst Stem Cells Res Ctr, Semnan, Iran
[7] Shahid Beheshti Univ Med Sci, Fac Med, Dept Med Microbiol, Tehran, Iran
[8] Shahed Univ, Fac Med, Dept Med Microbiol, Tehran, Iran
关键词
JAK/STAT signaling pathway; Antiviral; Inflammation; Interferon; Cytokine; INTERLEUKIN-2-RECEPTOR BETA-CHAIN; JANUS KINASE; RHEUMATOID-ARTHRITIS; TYROSINE KINASE; STAT PATHWAY; THERAPEUTIC STRATEGIES; GENE-EXPRESSION; JAK INHIBITORS; GROWTH-FACTOR; IFN-ALPHA;
D O I
10.1186/s12964-023-01240-y
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
The Janus kinase/signal transducer and activator of transcription (JAK/STAT) is an intricate signaling cascade composed of various cytokines, interferons (IFN, growth factors, and other molecules. This pathway provides a delicate mechanism through which extracellular factors adjust gene expression, thereby acting as a substantial basis for environmental signals to influence cell growth and differentiation. The interactions between the JAK/STAT cascade and antiviral IFNs are critical to the host's immune response against viral microorganisms. Recently, with the emergence of therapeutic classes that target JAKs, the significance of this cascade has been recognized in an unprecedented way. Despite the functions of the JAK/STAT pathway in adjusting immune responses against viral pathogens, a vast body of evidence proposes the role of this cascade in the replication and pathogenesis of viral pathogens. In this article, we review the structure of the JAK/STAT signaling cascade and its role in immuno-inflammatory responses. We also highlight the paradoxical effects of this pathway in the pathogenesis of viral infections.3Hv_W2DfGsqDpHAacSMic3Video Abstract
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页数:17
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