Clinical standards for drug-susceptible TB in children and adolescents

被引：6

作者：

Chiang, S. S. ^{[1
,2
]}

Graham, S. M. ^{[3
,4
]}

Schaaf, H. S. ^{[5
]}

Marais, B. J. ^{[6
,7
,8
]}

Sant'Anna, C. C. ^{[9
]}

Sharma, S. ^{[10
]}

Starke, J. R. ^{[11
,12
]}

Triasih, R. ^{[13
]}

Achar, J. ^{[14
]}

Amanullah, F. ^{[15
,16
]}

Armitage, L. Y. ^{[17
]}

Aurilio, R. B. ^{[18
,19
]}

Buck, W. C. ^{[20
]}

Centis, R. ^{[21
]}

Chabala, C. ^{[22
,23
]}

Cruz, A. T. ^{[11
]}

Demers, A. -M. ^{[5
,24
]}

du Preez, K. ^{[5
]}

Enimil, A. ^{[25
,26
]}

Furin, J. ^{[27
,28
]}

Garcia-Prats, A. J. ^{[5
,29
]}

Gonzalez, N. E. ^{[30
,31
]}

Hoddinott, G. ^{[5
]}

Isaakidis, P. ^{[32
,33
]}

Jaganath, D. ^{[34
]}

Kabra, S. K. ^{[35
]}

Kampmann, B. ^{[36
,37
]}

Kay, A. ^{[11
]}

Kitai, I. ^{[38
,39
]}

Lopez-Varela, E. ^{[40
,41
]}

Maleche-Obimbo, E. ^{[42
]}

Malaspina, F. Mestanza ^{[43
,44
]}

Velasquez, J. Niederbacher ^{[45
,46
]}

Nuttall, J. J. C. ^{[47
]}

Oliwa, J. N. ^{[48
,49
]}

Andrade, I. Orozco ^{[50
,51
]}

Perez-Velez, C. M. ^{[52
]}

Rabie, H. ^{[53
]}

Seddon, J. A. ^{[5
,54
]}

Sekadde, M. P. ^{[55
]}

Shen, A. ^{[56
,57
]}

Skrahina, A. ^{[58
]}

Soriano-Arandes, A. ^{[59
,60
]}

Steenhoff, A. P. ^{[61
,62
,63
]}

Tebruegge, M. ^{[64
,65
]}

Tovar, M. A. ^{[66
,67
]}

Tsogt, B. ^{[68
]}

van der Zalm, M. M. ^{[5
]}

Welch, H. ^{[11
,69
]}

Migliori, G. B.

机构：

[1] Brown Univ, Dept Pediat, Div Pediat Infect Dis, Alpert Med Sch, Providence, RI USA

[2] Rhode Isl Hosp, Ctr Int Hlth Res, Providence, RI USA

[3] Univ Melbourne, Dept Paediat, Melbourne, Vic, Australia

[4] Burnet Inst, Melbourne, Vic, Australia

[5] Stellenbosch Univ, Fac Med & Hlth Sci, Desmond Tutu TB Ctr, Dept Paediat & Child Hlth, Cape Town, South Africa

[6] Dept Paediat & Child Hlth, Sydney, NSW, Australia

[7] Sydney Infect Dis Inst Sydney ID, Sydney, NSW, Australia

[8] Childrens Hosp Westmead, Dept Infect Dis, Sydney, NSW, Australia

[9] Univ Fed Rio de Janeiro, Dept Paediat, Rio De Janeiro, RJ, Brazil

[10] Natl Inst TB & Resp Dis, Dept Paediat, New Delhi, India

[11] Baylor Coll Med, Dept Pediat, Houston, TX USA

[12] Texas Childrens Hosp, Sect Infect Dis, Houston, TX USA

[13] Univ Gadjah Mada, Dept Paediat, Fac Med Publ Hlth & Nursing, Dr Sardjito Hosp, Yogyakarta, Indonesia

[14] Karolinska Inst, Dept Global Publ Hlth, Stockholm, Sweden

[15] Indus Hosp & Hlth Network, Dept Paediat, Karachi, Pakistan

[16] Aga Khan Univ Hosp, Dept Paediat, Karachi, Pakistan

[17] Univ Texas Hlth Sci Ctr Tyler, Heartland Natl TB Ctr, San Antonio, TX USA

[18] Univ Fed Rio de Janeiro, Dept Paediat, Inst Puericultura & Pediat Martagao Gesteira, Rio De Janeiro, RJ, Brazil

[19] Univ Estado Rio de Janeiro, Dept Paediat, Rio De Janeiro, RJ, Brazil

[20] Univ Calif Los Angeles, Dept Pediat, David Geffen Sch Med, Los Angeles, CA USA

[21] Ist Ricovero & Cura Carattere Sci, Resp Dis Clin Epidemiol Unit, Ist Clin Sci Maugeri, Tradate, Italy

[22] Univ Zambia, Sch Med, Dept Paediat & Child Hlth, Lusaka, Zambia

[23] Univ Teaching Hosp, Childrens Hosp, Lusaka, Zambia

[24] CHU St Justine, Dept Lab Med, Div Microbiol, Montreal, PQ, Canada

[25] Kwame Nkrumah Univ Sci & Technol, Dept Child Hlth, Kumasi, Ghana

[26] Komfo Anokye Teaching Hosp, Dept Child Hlth, Kumasi, Ghana

[27] Harvard Med Sch, Dept Global Hlth & Social Med, Boston, MA USA

[28] Case Western Reserve Univ, Dept Med, Div Infect Dis, Cleveland, OH USA

[29] Univ Wisconsin Madison, Dept Pediat, Madison, WI USA

[30] Hosp Ninos Pedro Elizalde, Div Neumotisiol, Buenos Aires, DF, Argentina

[31] Univ Buenos Aires, Fac Med, Direcc Gen Posgrad, Buenos Aires, DF, Argentina

[32] Med Sans Frontieres, Southern Africa Med Unit SAMU, Cape Town, South Africa

[33] Univ Ioannina, Dept Hyg & Epidemiol, Clin & Mol Epidemiol Unit, Sch Med, Ioannina, Greece

[34] Univ Calif San Francisco, Dept Pediat, Div Pediat Infect Dis, San Francisco, CA USA

[35] All India Inst Med Sci, Dept Paediat, New Delhi, India

[36] Charite Univ Med Berlin, Charite Ctr Global Hlth, Berlin, Germany

[37] London Sch Hyg & Trop Med, Clin Res Dept, London, England

[38] Hosp Sick Children, Dept Paediat, Toronto, ON, Canada

[39] Univ Toronto, Dept Pediat, Toronto, ON, Canada

[40] Univ Barcelona, Hosp Clin & ISGlobal, Barcelona, Spain

[41] Ctr Invest Saude Manhica CISM, Manhica, Mozambique

[42] Univ Nairobi, Dept Paediat & Child Hlth, Nairobi, Kenya

[43] Hosp San Bartolome, Dept Paediat, Lima, Peru

[44] Minist Salud, Red Peruana TB Pediat, Direcc Prevenc & Control TB, Lima, Peru

[45] Univ Ind Santander, Dept Paediat, Bucaramanga, Colombia

[46] Asociac Colombiana Neumol Pediat, Bogota, Colombia

[47] Univ Cape Town, Dept Paediat & Child Hlth, Paediat Infect Dis Unit, Cape Town, South Africa

[48] Univ Nairobi, Fac Hlth Sci, Dept Paediat & Child Hlth, Nairobi, Kenya

[49] Kenya Med Res Inst Wellcome Trust Res Programme, Hlth Serv Unit, Nairobi, Kenya

[50] Serv Med Frontera, Ctr Diag & Integral Treatment TB, Juarez, Mexico

来源：

INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE | 2023年 / 27卷 / 08期

基金：

美国国家卫生研究院;

关键词：

diagnosis; treatment; meningeal tuberculosis; miliary tuberculosis; tuberculosis infection; HIV; CHILDHOOD TUBERCULOUS MENINGITIS; RESISTANT TUBERCULOSIS; TREATMENT OUTCOMES; GLOBAL BURDEN; DISEASE; INFECTION; CARE; VACCINATION; PREVENTION; MANAGEMENT;

D O I：

10.5588/ijtld.23.0085

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

BACKGROUND: These clinical standards aim to provide guidance for diagnosis, treatment, and management of drug-susceptible TB in children and adolescents.METHODS: Fifty-two global experts in paediatric TB participated in a Delphi consensus process. After eight rounds of revisions, 51/52 (98%) participants endorsed the final document.RESULTS: Eight standards were identified: Standard 1, Age and developmental stage are critical considerations in the assessment and management of TB; Standard 2, Children and adolescents with symptoms and signs of TB disease should undergo prompt evaluation, and diagnosis and treatment initiation should not depend on microbiological confirmation; Standard 3, Treatment initiation is particularly urgent in children and adolescents with presumptive TB meningitis and disseminated (miliary) TB; Standard 4, Children and adolescents should be treated with an appropriate weight-based regimen; Standard 5, Treating TB infection (TBI) is important to prevent disease; Standard 6, Children and adolescents should receive home-based/community-based treatment support whenever possible; Standard 7, Chil-dren, adolescents, and their families should be provided age-appropriate support to optimise engagement in care and clinical outcomes; and Standard 8, Case reporting and contact tracing should be conducted for each child and adolescent. CONCLUSION: These consensus-based clinical standards, which should be adapted to local contexts, will improve the care of children and adolescents affected by TB.

引用

页码：584 / 598

页数：15

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