Ethical, legal and social aspects of human cerebral organoids and their governance in Germany, the United Kingdom and the United States

被引：3

作者：

Pichl, Anja ^{[1
,2
]}

Ranisch, Robert ^{[1
,2
]}

Altinok, Ozan Altan ^{[3
]}

Antonakaki, Melpomeni ^{[4
]}

Barnhart, Andrew J. ^{[5
]}

Bassil, Katherine ^{[6
]}

Boyd, J. Lomax ^{[7
]}

Chinaia, Alice Andrea ^{[8
]}

Diner, Sarah ^{[9
]}

Gaillard, Maxence ^{[10
,11
]}

Greely, Henry T. ^{[12
]}

Jowitt, Joshua ^{[13
]}

Kreitmair, Karola ^{[14
]}

Lawrence, David ^{[15
]}

Lee, Tim Nicholas ^{[16
]}

Mckeown, Alex ^{[17
]}

Sachdev, Vorathep ^{[16
]}

Schicktanz, Silke ^{[18
]}

Sugarman, Jeremy ^{[19
,20
]}

Trettenbach, Katharina ^{[1
,2
]}

Wiese, Lara ^{[21
]}

Wolff, Hannes ^{[22
]}

Arnason, Garoar ^{[2
,23
]}

机构：

[1] Univ Potsdam, Fac Hlth Sci Brandenburg, Potsdam, Germany

[2] Univ Tubingen, Inst Eth & Hist Med, Res Unit Eth Genome Editing, Tubingen, Germany

[3] Leibniz Univ Hannover, Ctr Eth & Law Life Sci, Hannover, Germany

[4] Tech Univ Munich, Dept Sci Technol & Soc, Munich, Germany

[5] Katholieke Univ Leuven, Ctr Biomed Eth & Law, Leuven, Belgium

[6] Maastricht Univ, Dept Psychiat & Neuropsychol, Maastricht, Netherlands

[7] Johns Hopkins Univ, Berman Inst Bioeth, Baltimore, MD USA

[8] IMT Sch Adv Studies, Lucca, Italy

[9] Univ Bonn, Inst Med Humanities, Med Fac, Bonn, Germany

[10] Univ Oslo, HYBRIDA Project, Oslo, Norway

[11] UCLouvain, Louvain La Neuve, Belgium

[12] Stanford Univ, Stanford Law Sch, Stanford, CA USA

[13] Newcastle Univ, Newcastle Law Sch, Newcastle Upon Tyne, Tyne & Wear, England

[14] Univ Wisconsin Madison, Sch Med & Publ Hlth, Dept Med Hist & Bioeth, Madison, WI USA

[15] Univ Durham, Durham Law Sch, Durham, England

[16] Univ Edinburgh, Edinburgh Infect Dis, Edinburgh, Scotland

[17] Univ Oxford, Wellcome Ctr Eth & Humanities, Dept Psychiat, Oxford, England

[18] Univ Med Ctr Gottingen, Dept Med Eth & Hist Med, Gottingen, Germany

[19] Johns Hopkins Univ, Berman Inst Bioeth, Baltimore, MD USA

[20] Johns Hopkins Univ, Dept Med, Baltimore, MD USA

[21] Ruhr Univ Bochum, Inst Social & Hlth Law, Bochum, Germany

[22] Univ Passau, Fac Law, Chair Constitut & Adm Law, Publ Int Law,European & Int Econ Law, Passau, Germany

[23] Univ Akureyri, Sch Humanities & Social Sci, Akureyri, Iceland

来源：

FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY | 2023年 / 11卷

关键词：

brain organoid; human cerebral organoids; ELSA; ethics; consciousness; moral status; governance; public engagement; CONSCIOUSNESS; ISSUES;

D O I：

10.3389/fcell.2023.1194706

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Human cerebral organoids (HCOs) are model systems that enable researchers to investigate the human brain in ways that had previously been impossible. The emergence of HCOs was accompanied by both expert and layperson discussions concerning the possibility of these novel entities developing sentience or consciousness. Such concerns are reflected in deliberations about how to handle and regulate their use. This perspective article resulted from an international and interdisciplinary research retreat "Ethical, Legal and Social Aspects of Human Cerebral Organoids and their Governance in Germany, the United Kingdom and the United States", which took place in Tubingen, Germany, in August 2022. The retreat focused on whether HCO research requires new ethical and regulatory approaches. It addressed epistemic issues around the detection and theorisation of consciousness, ethical concerns around moral status and research conduct, difficulties for legislation and guidelines managing these entities, and public engagement.

引用

页数：6

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