A model based on meta-analysis to evaluate poor prognosis of patients with severe fever with thrombocytopenia syndrome

被引:2
|
作者
Liu, Zishuai [1 ]
Jiang, Zhouling [1 ]
Zhang, Ligang [2 ]
Xue, Xiaoyu [1 ]
Zhao, Chenxi [1 ]
Xu, Yanli [2 ]
Zhang, Wei [1 ]
Lin, Ling [2 ]
Chen, Zhihai [1 ]
机构
[1] Capital Med Univ, Beijing Ditan Hosp, Dept Infect Dis, Beijing, Peoples R China
[2] Yantai Qishan Hosp, Dept Infect Dis, Yantai, Peoples R China
基金
中国国家自然科学基金;
关键词
SFTS; risk factors; meta-analysis; prediction model; cohort study; SYNDROME VIRUS; PATHOGENESIS; BUNYAVIRUS; CHINA;
D O I
10.3389/fmicb.2023.1307960
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
Background: Early identification of risk factors associated with poor prognosis in Severe fever with thrombocytopenia syndrome (SFTS) patients is crucial to improving patient survival. Method: Retrieve literature related to fatal risk factors in SFTS patients in the database, extract the risk factors and corresponding RRs and 95% CIs, and merge them. Statistically significant factors were included in the model, and stratified and assigned a corresponding score. Finally, a validation cohort from Yantai Qishan Hospital in 2021 was used to verify its predictive ability. Result: A total of 24 articles were included in the meta-analysis. The model includes six risk factors: age, hemorrhagic manifestations, encephalopathy, Scr and BUN. The analysis of lasso regression and multivariate logistic regression shows that model score is an independent risk factor (OR = 1.032, 95% CI 1.002-1.063, p = 0.034). The model had an area under the curve (AUC) of 0.779 (95% CI 0.669-0.889, P<0.001). The validation cohort was divided into four risk groups with cut-off values. Compared with the low-medium risk group, the mortality rate of high-risk and very high-risk patients was more significant (RR =5.677, 95% CI 4.961-6.496, P<0.001). Conclusion: The prediction model for the fatal outcome of SFTS patients has shown positive outcomes.
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页数:9
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