Early-life microbiota-immune homeostasis

被引：1
|
作者：
Reynolds, Hayley M. [1 ]
Bettini, Matthew L. [1 ]
机构：
[1] Univ Utah, Dept Microbiol & Immunol, Salt Lake City, UT 84112 USA
来源：
FRONTIERS IN IMMUNOLOGY | 2023年 / 14卷
基金：
美国国家卫生研究院;
关键词：
gut microbiota; dysbiosis; early-life; probiotics; prebiotics; fecal microbiota transplant; immune homeostasis; REGULATORY T-CELLS; PROBIOTIC SUPPLEMENTATION; B-CELLS; COMMENSAL; RESPONSES; MYCOBACTERIA; TOLERANCE; EXPOSURE; DELIVERY; HYGIENE;
D O I：
10.3389/fimmu.2023.1266876
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
As the prevalence of allergy and autoimmune disease in industrialized societies continues to rise, improving our understanding of the mechanistic roles behind microbiota-immune homeostasis has become critical for informing therapeutic interventions in cases of dysbiosis. Of particular importance, are alterations to intestinal microbiota occurring within the critical neonatal window, during which the immune system is highly vulnerable to environmental exposures. This review will highlight recent literature concerning mechanisms of early-life microbiota-immune homeostasis as well as discuss the potential for therapeutics in restoring dysbiosis in early life.
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