Palladium-Catalyzed Regio- and Enantioselective Hydrophosphination of gem-Difluoroallenes

Chiral allylic phosphines and gem-difluoroalkenesare both important structural motifs in various bioactive molecules,chiral ligands, and natural products. These two motifs are now integrated,and we herein report a straightforward and atom-economical enantioselectivehydrophosphination of gem-difluoroallenes using disubstitutedphosphines. A wide array of enantioenriched fluorinated allylic phosphineshas been accessed with excellent regio- and enantioselectivity andhigh efficiency. Synthetic and catalytic applications of phosphineproducts have been demonstrated.