Polysaccharide and Cyclodextrin-Based Monolithic Chiral Stationary Phases and its Application to Chiral Separation

被引：6
|
作者：
Aboul-Enein, Hassan Y. [1 ]
Kannappan, Valliappan [2 ]
Kanthiah, Selvakumar [3 ]
机构：
[1] Natl Res Ctr, Pharmaceut & Med Chem Dept, Pharmaceut & Drug Ind Res Div, Cairo, Egypt
[2] Annamalai Univ, Dept Pharm, Chidambaram 608002, Tamil Nadu, India
[3] Acharya & BM Reddy Coll Pharm, Dept Qual Assurance, Bengaluru, India
来源：
COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING | 2023年 / 26卷 / 15期
关键词：
Monolith chiral stationary phases; polysaccharide; cyclodextrin; chiral separation; chiral chromatography; liquid chromatography; LIQUID-CHROMATOGRAPHIC-SEPARATION; COVALENTLY BONDED CELLULOSE; AMINO-ACID ENANTIOMERS; ONE-STEP STRATEGY; ONE-POT STRATEGY; BETA-CYCLODEXTRIN; CAPILLARY ELECTROCHROMATOGRAPHY; POLYMER MONOLITHS; NEUTRAL COMPOUNDS; SILICA COLUMNS;
D O I：
10.2174/1386207326666230208094859
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
The recent development of monolithic chiral stationary phases (CSPs) for liquid chromatography (LC) is mainly focused on reducing backpressure, maximizing flow rates, faster run time, column efficiency, and stability. This review paper emphasizes recent progress in the development of polysaccharide and cyclodextrin-based monolithic CSPs. Further the paper draws attention to competing techniques, like non-porous particle-packed columns, core-shell and monoliths as chromatographic support matrix, available for achieving fast and efficient chromatographic separation. A brief discussion on the three main classes of chiral monolithic stationary phase viz. silica, organic polymer and hybrid-based monolithic stationary phases is also presented. In addition, the paper highlights various studies on the application of monolith chiral CSPs in LC and capillary electrochromrography separation and analysis of chiral compounds.
引用
收藏
页码：2583 / 2597
页数：15
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