IRREVERSIBLE ELECTROPORATION FOR CAN- CER TREATMENT: A REVIEW

Introduction: Prostate, pancreatic and liver cancers are a major cause of death in Europe and including Bul-garia. Some methods for treatment include the use of elec-tric current to create pores in the cells' membranes, and can be used in combination with other techniques, while an electric field with enough strength causes irreversible electroporation (IRE) and is a separate technique. Material and methods: Search was conducted for scientific articles about electroporation and IRE. Results: Most important parameters reported in sci-entific articles are electric field distribution, tissue char-acteristics and interaction, electric pulse settings. Articles that report patient outcomes suggest several possible ad-vantages of - retaining urinary and sexual functions, pos-sible increase of overall survival rate, low rate of serious adverse events and promising results when applied with chemotherapy. However, there are some studies that do not corroborate these results. The technique is also used for the treatment of renal cancer, and there are researches in-dicating a potential for use in ovarian, cervical and breast cancer. Conclusion: Studies suggest the IRE method is safe and feasible for the treatment of prostate cancer, pancre-atic cancer and liver cancer, but improvements in the protocols is needed to prevent a decrease of quality of life. in tate son rope the mined threshold membranes, called field bilayer tric stabilize edge Public