Impact of donor sex on hepatocellular carcinoma recurrence in liver transplantation after brain death

Background: Hepatocellular carcinoma (HCC) is predominantly seen in males but has a better prognosis in females. No prior studies have investigated HCC recurrence based on sex combination following liver transplant donated after brain death (DBDLT). This study sought to elucidate the effects of donor and recipient sex on HCC recurrence rates. Methods: 9232 adult recipients from the United Network for Organ Sharing (UNOS) database who underwent DBDLT for HCC from 2012 to 2018 were included. Donorrecipient pairs were divided into (1) female donor/female recipient (F-F) (n = 1089); (2) male donor/female recipient (M-F) (n = 975); (3) female donor/male recipient (F-M) (n = 2691); (4) male donor/male recipient (M-M) (n = 4477). The primary prognostic outcome was HCC recurrence. A multivariable competing risk regression analysis was used to assess prognostic influences. Results: Themedian recipient age and model for end-stage liver disease (MELD) scores were similar among the four groups. Livers ofmale recipients demonstrated greater in size and number of HCC (both p-values were <.0001). There was also a higher rate of vascular invasion in male recipients compared to female (p <.0001). Competing risk analyses showed that the cumulative HCC recurrence rate was significantly lower in the M-F group (p =.013). After adjusting for tumor characteristics, liver grafts from male donors were associated with a lower HCC recurrence rate in female recipients (HR:.62 95%CI:.42-.93) (p =.021). Conclusion: In DBDLT, male donor to female recipient pairing exhibited lower HCC recurrence rates.