Spatial landscape of the tumor immune microenvironment

Two recent studies published in Nature by Karimi et al. and Sorin et al. applied multiplexed imaging mass cytometry (IMC) to characterize the single-cell tumor immune landscapes covering millions of cells in brain tumors and lung adenocarcinomas (LUAD). They identified specific cell subtypes and cell- cell interactions that correlate with distinct clinical outcomes, thus providing valuable insights into tumor biology and prognostic prediction based on spatial architecture.