Considerations for Creating the Next Generation of RNA Therapeutics: Oligonucleotide Chemistry and Innate Immune Responses to Nucleic Acids

被引:0
|
作者
Agrawal, Sudhir [1 ]
机构
[1] Arnay Sci, Maple Ave,POB 519, Shrewsbury, MA 01545 USA
关键词
HUMAN-IMMUNODEFICIENCY-VIRUS; TOLL-LIKE RECEPTORS; MIXED-BACKBONE OLIGONUCLEOTIDES; OLIGODEOXYNUCLEOTIDE PHOSPHOROTHIOATE GEM-91; PHASE STEREOSELECTIVE-SYNTHESIS; IN-VIVO STABILITY; ANTISENSE OLIGONUCLEOTIDES; IMMUNOSTIMULATORY ACTIVITY; MESSENGER-RNA; CHEMICAL-MODIFICATIONS;
D O I
10.1089/nat.2024.29009.sud
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
[No abstract available]
引用
收藏
页码:37 / 51
页数:15
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  • [1] Chemistry of Artificial Nucleic Acid and Oligonucleotide Therapeutics Based on Natural Nucleic Acids
    Taniguchi, Yosuke
    [J]. JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN, 2018, 76 (05) : 482 - 485
  • [2] Spherical nucleic acids: Making a case for next-generation nucleic acid therapeutics
    Mirkin, Chad
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2017, 253
  • [3] Editorial overview: Next generation therapeutics: Creating and exploiting the chemistry numbers
    Scheuermann, Joerg
    Neri, Dario
    [J]. CURRENT OPINION IN CHEMICAL BIOLOGY, 2015, 26 : IV - V
  • [4] Modified nucleic acids: replication, evolution, and next-generation therapeutics
    Duffy, Karen
    Arangundy-Franklin, Sebastian
    Holliger, Philipp
    [J]. BMC BIOLOGY, 2020, 18 (01)
  • [5] Modified nucleic acids: replication, evolution, and next-generation therapeutics
    Karen Duffy
    Sebastian Arangundy-Franklin
    Philipp Holliger
    [J]. BMC Biology, 18
  • [6] Emerging roles of the processing of nucleic acids and Toll-like receptors in innate immune responses to nucleic acids
    Miyake, Kensuke
    Shibata, Takuma
    Ohto, Umeharu
    Shimizu, Toshiyuki
    [J]. JOURNAL OF LEUKOCYTE BIOLOGY, 2017, 101 (01) : 135 - 142
  • [7] Innate immune responses triggered by nucleic acids inspire the design of immunomodulatory nucleic acid nanoparticles (NANPs)
    Chandler, Morgan
    Johnson, Morgan Brittany
    Panigaj, Martin
    Afonin, Kirill A.
    [J]. CURRENT OPINION IN BIOTECHNOLOGY, 2020, 63 : 8 - 15
  • [8] How the initial discovery of modified RNA enabled evasion of innate immune responses and facilitated the development of RNA therapeutics
    Sioud, Mouldy
    [J]. SCANDINAVIAN JOURNAL OF IMMUNOLOGY, 2023, 98 (01)
  • [9] Activation of Innate Immune Responses by a Cytosine-Phosphate-Guanine Oligonucleotide Sequence Composed Entirely of Threose Nucleic Acid
    Lange, Margaret J.
    Burke, Donald H.
    Chaput, John C.
    [J]. NUCLEIC ACID THERAPEUTICS, 2019, 29 (01) : 51 - 59
  • [10] PRINS Non-Coding RNA Regulates Nucleic Acid-Induced Innate Immune Responses of Human Keratinocytes
    Danis, Judit
    Goblos, Aniko
    Bata-Csorg, Zsuzsanna
    Kemeny, Lajos
    Szell, Marta
    [J]. FRONTIERS IN IMMUNOLOGY, 2017, 8