Biological effects and mechanisms of fisetin in cancer: a promising anti-cancer agent

被引：8
|
作者：
Zhou, Chenhui [1 ,2 ]
Huang, Yi [1 ,2 ]
Nie, Sheng [2 ]
Zhou, Shengjun [2 ]
Gao, Xiang [1 ,2 ]
Chen, Gao [1 ,3 ]
机构：
[1] Zhejiang Univ, Sch Med, Hangzhou 310009, Peoples R China
[2] Ningbo First Hosp, Dept Neurosurg, Ningbo 315300, Peoples R China
[3] Zhejiang Univ, Affiliated Hosp 2, Sch Med, Dept Neurosurg, Hangzhou, Peoples R China
来源：
EUROPEAN JOURNAL OF MEDICAL RESEARCH | 2023年 / 28卷 / 01期
基金：
中国国家自然科学基金;
关键词：
Fisetin; Cancer; Anticancer therapy; Biological function; Signal pathways; DIETARY FLAVONOID FISETIN; NF-KAPPA-B; CELLS; PROLIFERATION; APOPTOSIS; MIGRATION; PATHWAY;
D O I：
10.1186/s40001-023-01271-8
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Fisetin, a natural flavonoid, possesses numerous biological activities that have been extensively studied in various diseases. When it comes to cancer, fisetin exhibits a range of biological effects, such as suppressing cell growth, triggering programmed cell death, reducing the formation of new blood vessels, protecting against oxidative stress, and inhibiting cell migration. Moreover, fisetin has the ability to enhance the effectiveness of chemotherapy. The anticancer properties of fisetin can be attributed to a diverse array of molecules and signaling pathways, including vascular endothelial growth factor (VEGF), mitogen-activated protein kinase (MAPK), nuclear factor-kappa B (NF-kappa B), PI3K/Akt/mTOR, and Nrf2/HO-1. Consequently, fisetin holds promise as a therapeutic agent for anticancer treatment. In this review, we place emphasis on the biological functions and various molecular targets of fisetin in anticancer therapy.
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页数：10
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