Gaps in national healthcare spending and disparities in cancer mortality rates are noted across counties in the US. This study investigated whether differences in local county-level social vulnerability impacts cancer-related mortality. Substantial gaps in national healthcare spending and disparities in cancer mortality rates are noted across counties in the US. In this cross-sectional analysis, we investigated whether differences in local county-level social vulnerability impacts cancer-related mortality. We linked county-level age-adjusted mortality rates (AAMR) from the Centers for Disease Control and Prevention (CDC) Wide-ranging Online Data for Epidemiologic Research database, to county-level Social Vulnerability Index (SVI) from the CDC Agency for Toxic Substances and Disease Registry. SVI is a metric comprising 15 social factors including socioeconomic status, household composition and disability, minority status and language, and housing type and transportation. AAMRs were compared between least and most vulnerable counties using robust linear regression models. There were 4 107 273 deaths with an overall AAMR of 173 per 100 000 individuals. Highest AAMRs were noted in older adults, men, non-Hispanic Black individuals, and rural and Southern counties. Highest mortality risk increases between least and most vulnerable counties were noted in Southern and rural counties, individuals aged 45-65, and lung and colorectal cancers, suggesting that these groups may face highest risk for health inequity. These findings inform ongoing deliberations in public health policy at the state and federal level and encourage increased investment into socially disadvantaged counties.
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Univ Texas MD Anderson Canc Ctr, Div Canc Med, Houston, TX 77030 USAUniv Texas MD Anderson Canc Ctr, Div Canc Med, Houston, TX 77030 USA
LaPelusa, Michael
Diaz, Fernando Cristobal
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Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC USAUniv Texas MD Anderson Canc Ctr, Div Canc Med, Houston, TX 77030 USA
Diaz, Fernando Cristobal
Santos, Patricia Mae G.
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Mem Sloan Kettering Canc Ctr, Dept Radiat Oncol, New York, NY USAUniv Texas MD Anderson Canc Ctr, Div Canc Med, Houston, TX 77030 USA
Santos, Patricia Mae G.
Verduzco-Aguirre, Haydee
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Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Hematooncol, Mexico City, MexicoUniv Texas MD Anderson Canc Ctr, Div Canc Med, Houston, TX 77030 USA
Verduzco-Aguirre, Haydee
Soto-Perez-de-Celis, Enrique
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Inst Nacl Ciencias Med & Nutr Salvador Zubiran, Dept Geriatr, Mexico City, MexicoUniv Texas MD Anderson Canc Ctr, Div Canc Med, Houston, TX 77030 USA
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STChealth LLC, Div Epidemiol, Dept Data Analyt, Phoenix, AZ 85004 USASTChealth LLC, Div Epidemiol, Dept Data Analyt, Phoenix, AZ 85004 USA
Freese, Kyle E.
Vega, Antonio
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STChealth LLC, Dept Data Analyt, Phoenix, AZ USASTChealth LLC, Div Epidemiol, Dept Data Analyt, Phoenix, AZ 85004 USA
Vega, Antonio
Lawrence, J. Joseph
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USAID Southern Africa, Pretoria, South AfricaSTChealth LLC, Div Epidemiol, Dept Data Analyt, Phoenix, AZ 85004 USA
Lawrence, J. Joseph
Documet, Patricia, I
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Univ Pittsburgh, Grad Sch Publ Hlth, Dept Behav & Community Hlth Sci, Pittsburgh, PA USASTChealth LLC, Div Epidemiol, Dept Data Analyt, Phoenix, AZ 85004 USA
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Ohio State Univ, Wexner Med Ctr, Dept Surg, Div Surg Oncol, Columbus, OH USA
James Comprehens Canc Ctr, Columbus, OH USAOhio State Univ, Wexner Med Ctr, Dept Surg, Div Surg Oncol, Columbus, OH USA
Khan, Muhammad Muntazir Mehdi
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Munir, Muhammad Musaab
Khalil, Mujtaba
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Ohio State Univ, Wexner Med Ctr, Dept Surg, Div Surg Oncol, Columbus, OH USA
James Comprehens Canc Ctr, Columbus, OH USAOhio State Univ, Wexner Med Ctr, Dept Surg, Div Surg Oncol, Columbus, OH USA
Khalil, Mujtaba
Tsilimigras, Diamantis I.
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Ohio State Univ, Wexner Med Ctr, Dept Surg, Div Surg Oncol, Columbus, OH USA
James Comprehens Canc Ctr, Columbus, OH USAOhio State Univ, Wexner Med Ctr, Dept Surg, Div Surg Oncol, Columbus, OH USA
Tsilimigras, Diamantis I.
Woldesenbet, Selamawit
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Ohio State Univ, Wexner Med Ctr, Dept Surg, Div Surg Oncol, Columbus, OH USA
James Comprehens Canc Ctr, Columbus, OH USAOhio State Univ, Wexner Med Ctr, Dept Surg, Div Surg Oncol, Columbus, OH USA
Woldesenbet, Selamawit
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Endo, Yutaka
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Katayama, Erryk
Rashid, Zayed
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Ohio State Univ, Wexner Med Ctr, Dept Surg, Div Surg Oncol, Columbus, OH USA
James Comprehens Canc Ctr, Columbus, OH USAOhio State Univ, Wexner Med Ctr, Dept Surg, Div Surg Oncol, Columbus, OH USA
Rashid, Zayed
Cunningham, Lisa
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James Comprehens Canc Ctr, Columbus, OH USA
Ohio State Univ, Wexner Med Ctr, Dept Surg, Div Colorectal Surg, Columbus, OH USAOhio State Univ, Wexner Med Ctr, Dept Surg, Div Surg Oncol, Columbus, OH USA
Cunningham, Lisa
Kaladay, Matthew
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James Comprehens Canc Ctr, Columbus, OH USA
Ohio State Univ, Wexner Med Ctr, Dept Surg, Div Colorectal Surg, Columbus, OH USAOhio State Univ, Wexner Med Ctr, Dept Surg, Div Surg Oncol, Columbus, OH USA