Neoadjuvant Chemo-Endocrine Therapy for Hormone Receptor Positive Breast Cancer: A Meta-Analysis

被引：0
|
作者：
Li, Zhen-Yu [1 ]
Dong, Ying-Li [2 ]
Cao, Xiao-Zhong [1 ]
Ren, Sha-Sha [1 ]
Zhang, Zhen [1 ]
Matsubara, Shigeki
机构：
[1] Zhengzhou Univ, Luoyang Cent Hosp, Dept Breast Surg, Luoyang 471000, Henan, Peoples R China
[2] Zhengzhou Univ, Luoyang Cent Hosp, Dept Stomatol, Luoyang 471000, Henan, Peoples R China
来源：
CLINICAL AND EXPERIMENTAL OBSTETRICS & GYNECOLOGY | 2023年 / 50卷 / 04期
关键词：
breast cancer; neoadjuvant chemotherapy; neoadjuvant chemo-endocrine therapy; pathological complete response; ADJUVANT CHEMOTHERAPY; POSTMENOPAUSAL PATIENTS; RANDOMIZED-TRIAL; MULTICENTER; CONCURRENT; TAMOXIFEN;
D O I：
10.31083/j.ceog5004074
中图分类号：
R71 [妇产科学];
学科分类号：
100211 ;
摘要：
Background: Neoadjuvant chemotherapy has become the standard treatment for patients with locally advanced breast cancer. However, patients with hormone receptor positive (especially human epidermal growth receptor 2 negative) breast cancer show low response rate to neoadjuvant chemotherapy. Whether neoadjuvant chemo-endocrine therapy (NCET) can improve the pathological complete response (pCR) rate of these patients remains controversial.Methods: A systematic literature search was conducted in the PubMed, Embase, and Cochrane databases. Pooled odds ratio (OR) with 95% confidence intervals (CI) was calculated.Results: Five randomized controlled trials were included (N = 566). NCET did not significantly improve pCR (OR 1.35, 95% CI 0.77-2.38, p = 0.30).Conclusions: NCET did not to improve the pCR rates in patients with hormone receptor positive breast cancer.
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页数：6
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