Coeliac disease: what can we learn from prospective studies about disease risk?

被引：1

作者：

Stahl, Marisa ^{[1
,6
]}

Koletzko, Sibylle ^{[2
,3
]}

Aronsson, Carin Andren ^{[4
]}

Lindfors, Katri ^{[5
]}

Liu, Edwin ^{[1
]}

Agardh, Daniel ^{[4
]}

Group, T. E. D. D. Y. Study

机构：

[1] Univ Colorado, Digest Hlth Inst, Sch Med, Dept Pediat, Anschutz Med Campus, Aurora, CO USA

[2] Ludwig Maximilians Univ Munchen, Univ Hosp, Munich, Germany

[3] Medicum Univ Warm & Mazury, Dept Pediat, Gastroenterol & Nutr, Sch Med Coll, Olsztyn, Poland

[4] Lund Univ, Dept Clin Sci, Unit Celiac Dis & Diabet, Malmo, Sweden

[5] Tampere Univ, Fac Med & Hlth Technol, Celiac Dis Res Ctr, Tampere, Finland

[6] Univ Colorado Anschutz Med Campus, Digest Hlth Inst, Sch Med, Dept Pediat, Aurora, CO 80045 USA

来源：

LANCET CHILD & ADOLESCENT HEALTH | 2024年 / 8卷 / 01期

基金：

美国国家卫生研究院;

关键词：

GENETICALLY SUSCEPTIBLE CHILDREN; GLUTEN INTRODUCTION; MULTIPLE COMMON; AUTOIMMUNITY; PREGNANCY; DIAGNOSIS; BIRTH; ASSOCIATION; INFECTIONS; CHILDHOOD;

D O I：

10.1016/S2352-4642(23)00232-8

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Paediatric prospective studies of coeliac disease with longitudinal collection of biological samples and clinical data offer a unique perspective on disease risk. This Review highlights the information now available from international paediatric prospective studies on genetic and environmental risk factors for coeliac disease. In addition, recent omics studies have made it possible to study complex interactions between genetic and environmental factors and thereby further our insight into the causes of the disease. In the future, paediatric prospective studies will be able to provide more detailed risk prediction models combining genes, the environment, and biological corroboration from multiomics. Such studies could also contribute to biomarker development and an improved understanding of disease pathogenesis.

引用

页码：63 / 74

页数：12

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