Impact of Disease Modifying Therapy on MS-Related Fatigue: A Narrative Review

被引：1
|
作者：
Elkhooly, Mahmoud [1 ,2 ,3 ]
Bao, Fen [2 ]
Bernitsas, Evanthia [2 ]
机构：
[1] Southern Illinois Univ, Sch Med, Dept Neurol, Springfield, IL 62702 USA
[2] Wayne State Univ, Sch Med, Dept Neurol, Detroit, MI 48201 USA
[3] Minia Univ, Dept Neurol & Psychiat, Al Minya 61519, Egypt
来源：
BRAIN SCIENCES | 2024年 / 14卷 / 01期
关键词：
multiple sclerosis; fatigue; disease modifying therapies; QUALITY-OF-LIFE; RELAPSING MULTIPLE-SCLEROSIS; PLACEBO-CONTROLLED TRIAL; REAL-WORLD EFFECTIVENESS; GLATIRAMER ACETATE; ORAL FINGOLIMOD; INTERFERON-BETA; NATALIZUMAB; PATIENT; SAFETY;
D O I：
10.3390/brainsci14010004
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Multiple sclerosis (MS) is a chronic autoimmune disease that affects the central nervous system by causing inflammation, demyelination and neurodegeneration. Fatigue is the most prevalent and one of the most disabling symptoms among people with MS (pwMS). Due to its complexity and subjective character, fatigue is still little understood despite its frequent occurrence and severe impact. The potential causes, effects, and treatments of fatigue associated with MS have been extensively studied in recent years. Though the benefits of such a variety of contributions are obvious, there have not been many attempts to evaluate the effect of disease modifying therapies (DMTs) on MS-related fatigue. In this review, we summarize clinical trials and research studies, and we discuss the effect of different DMTs on MS-related fatigue.
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页数：12
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