Chemical composition and acetylcholinesterase inhibitory activity of essential oil from the leaves of Mitrephora poilanei Weeras. & RMK Saunders

被引：2

作者：

Doan, Tuan Quoc ^{[1
]}

Dinh, Dien ^{[2
]}

Tran, Thang Nam ^{[3
]}

Nguyen, Phu Quynh Dinh ^{[1
]}

Nguyen, Chau Bao Hoai ^{[1
]}

Le, Nhan Trong ^{[1
]}

Vo, Hung Quoc ^{[1
]}

Ho, Duc Viet ^{[1
]}

Tuan, Anh Le ^{[4
]}

Nguyen, Hoai Thi ^{[1
]}

Ogunwande, Isiaka A. ^{[5
]}

机构：

[1] Hue Univ, Hue Univ Med & Pharm, Fac Pharm, Hue city, Vietnam

[2] Phong Dien Nat Reserve, Phong Dien, Thua Thien Hue, Vietnam

[3] Hue Univ, Hue Univ Agr & Forestry, Fac Forestry, Hue City, Vietnam

[4] Vietnam Natl Museum Nat VAST, Mien Trung Inst Sci Res, Hanoi, Thua Thien Hue, Vietnam

[5] Aleku Area, Univ Rd, Osogbo, Nigeria

来源：

NATURAL PRODUCT RESEARCH | 2024年 / 38卷 / 11期

关键词：

Mitrephora poilanei; beta-caryophyllene; terpenes; IC50; AChE;

D O I：

10.1080/14786419.2023.2227989

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

The present study provides the first information on the chemical composition and acetylcholinesterase inhibitory activity of the essential oil (EO) from the leaves of Mitrephora poilanei Weeras. & R.M.K.Saunders from Vietnam. Gas chromatography and gas chromatography-mass spectrometry analysis revealed that the main components of the M. poilanei EO were beta-caryophyllene (13.2%), a-humulene (10.5%), germacrene D (8.1%), beta-elemene (5.2%) and bicyclogermacrene (5.1%). The anti-acetylcholinesterase assay showed that the EO displayed moderate activity with IC50 value of 31.16 +/- 3.06 mu g/mL. These findings proposed that the plant can be exploited for its anti-acetylcholinestrate potential.

引用

页码：1882 / 1886

页数：5

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