Congenital hypogonadotrophic hypogonadism, induction of minipuberty, and future fertility

被引：2
|
作者：
Stuckey, Bronwyn G. A. [1 ,2 ,3 ]
Nolan, James D. [2 ]
Hurley, David M. [4 ]
Martin, Graeme B. [5 ]
机构：
[1] Keogh Inst Med Res, Nedlands, WA, Australia
[2] Sir Charles Gairdner Hosp, Dept Endocrinol & Diabet, Nedlands, WA, Australia
[3] Univ Western Australia, Sch Med, Nedlands, WA, Australia
[4] Royal Perth Hosp, Dept Endocrinol & Diabet, Perth, WA, Australia
[5] Univ Western Australia, Sch Agr & Environm, Nedlands, WA, Australia
来源：
ENDOCRINOLOGY DIABETES AND METABOLISM CASE REPORTS | 2023年 / 2023卷 / 03期
基金：
英国医学研究理事会;
关键词：
Adult; Male; White; Australia; Testes; Puberty; Novel treatment; July; 2023;
D O I：
10.1530/EDM-23-0038
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
A 33-year-old man with Kallmann syndrome had received pulsatile GnRH as an infant for the treatment of cryptorchidism. As an adult, his treatment for fertility with gonadotrophins was unusually rapid compared with expectations, with a total sperm count of 25 million after only 12 months of gonadotrophin therapy. We propose that pulsatile GnRH treatment as an infant induced minipuberty and facilitated his successful, rapid response to therapy. We also propose that identification of the absence of minipuberty in infants with clinical signs suggesting congenital hypogonadotrophic hypogonadism (CHH) is an opportunity for intervention with pulsatile GnRH yielding benefits for fertility decades later.
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页数：5
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