Poly(2-Hydroxyethyl Methacrylate) Hydrogel-Based Microneedles for Metformin Release

被引：4

作者：

Sharma, Manoj B. ^{[1
,2
]}

Kap, Ozlem ^{[3
]}

Abdelmohsen, Hend A. M. ^{[1
,4
]}

Ashton, Mark D. ^{[1
]}

Harper, Garry R. ^{[1
]}

Firlak, Melike ^{[1
,5
]}

Aaltonen, Jasmine E. ^{[1
]}

Bolland, Kerry A. ^{[1
]}

Bragg, Ryan ^{[1
]}

Deeley, Sarah ^{[1
]}

Francis, Ella ^{[1
]}

Kazi, Nahin ^{[1
]}

Mapley, Bethany L. ^{[1
]}

Oikonomou, Vasileios ^{[1
]}

Aljohani, Amal D. ^{[1
,6
]}

Cheneler, David ^{[2
,7
]}

Kilic, Volkan ^{[8
]}

Horzum, Nesrin ^{[3
]}

Hardy, John G. ^{[1
,7
]}

机构：

[1] Univ Lancaster, Dept Chem, Lancaster LA1 4YB, England

[2] Univ Lancaster, Sch Engn, Lancaster LA1 4YW, England

[3] Izmir Katip Celebi Univ, Dept Engn Sci, TR-35620 Izmir, Turkiye

[4] Ain Shams Univ, Fac Pharm, Dept Pharmaceut & Ind Pharm, African Union Org St, Cairo 11566, Egypt

[5] Gebze Tech Univ, Dept Chem, TR-41400 Gebze, Turkiye

[6] King Abdulaziz Univ, Fac Sci, Dept Chem, Female Sect, Jeddah Rabbigh 21589, Saudi Arabia

[7] Univ Lancaster, Mat Sci Inst, Lancaster LA1 4YB, England

[8] Izmir Katip Celebi Univ, Dept Elect & Elect Engn, TR-35620 Izmir, Turkiye

来源：

GLOBAL CHALLENGES | 2023年 / 7卷 / 08期

基金：

英国工程与自然科学研究理事会;

关键词：

aging; cancer; diabetes; drug delivery; hydrogels; microneedles; SUBCUTANEOUS DELIVERY; DRUG-RELEASE; SKIN; CANCER; ARRAYS; SYSTEM; MODEL;

D O I：

10.1002/gch2.202300002

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The release of metformin, a drug used in the treatment of cancer and diabetes, from poly(2-hydroxyethyl methacrylate), pHEMA, hydrogel-based microneedle patches is demonstrated in vitro. Tuning the composition of the pHEMA hydrogels enables preparation of robust microneedle patches with mechanical properties such that they would penetrate skin (insertion force of a single microneedle to be & AP;40 N). Swelling experiments conducted at 20, 35, and 60 & DEG;C show temperature-dependent degrees of swelling and diffusion kinetics. Drug release from the pHEMA hydrogel-based microneedles is fitted to various models (e.g., zero order, first order, second order). Such pHEMA microneedles have potential application for transdermal delivery of metformin for the treatment of aging, cancer, diabetes, etc.

引用

页数：7

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