Differences in New Variant of Concern Replication at Physiological Temperatures In Vitro

被引：8
|
作者：
Stauft, Charles B. [1 ]
Sangare, Kotou [1 ]
Wang, Tony T. [1 ]
机构：
[1] US FDA, Div Viral Prod, Ctr Biol Evaluat & Res, Silver Spring, MD USA
来源：
JOURNAL OF INFECTIOUS DISEASES | 2023年 / 227卷 / 02期
关键词：
SARS-CoV-2; COVID-19; new variant of concern; Omicron variant; replication; transmission; temperature sensitivity; Delta variant;
D O I：
10.1093/infdis/jiac264
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Using multiple cell types and isolates of Delta and Omicron variants of SARS-CoV-2, we report differences in virus production, replication, and infectivity in vitro. Ancestral and Delta SARS-CoV-2 variant exhibit reduced virus production and replication at 34 degrees C compared to 37 degrees C while Omicron replication is balanced between temperatures.
引用
收藏
页码：202 / 205
页数：4
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