Long live lamins

Jin and Worman discuss work from Hasper and colleagues, who discovered that turnover of lamin A/C and progerin is substantially slower specifically in disease-afflicted tissues. Mutations in genes encoding nuclear lamins cause diseases called laminopathies. In this issue, Hasper et al. (https://doi.org/10.1083/jcb.202307049) show that lamin A/C and the prelamin A variant in Hutchinson-Gilford progeria syndrome have relatively long lifetimes in affected tissues.