Anti-Inflammatory and Anticancer Effects of Anticoagulant Therapy in Patients with Malignancy

被引：12

作者：

Russo, Vincenzo ^{[1
,2
]}

Falco, Luigi ^{[1
]}

Tessitore, Viviana ^{[1
]}

Mauriello, Alfredo ^{[1
]}

Catapano, Dario ^{[1
]}

Napolitano, Nicola ^{[1
]}

Tariq, Moiz ^{[1
]}

Caturano, Alfredo ^{[3
]}

Ciccarelli, Giovanni ^{[1
,2
]}

D'Andrea, Antonello ^{[3
,4
]}

Giordano, Antonio ^{[2
]}

机构：

[1] Univ Campania Luigi Vanvitelli, Monaldi Hosp, Dept Med Translat Sci, Cardiol Unit, I-80126 Naples, NA, Italy

[2] Temple Univ, Sbarro Inst Canc Res & Mol Med, Coll Sci & Technol, Ctr Biotechnol, Philadelphia, PA 19122 USA

[3] Univ Campania Luigi Vanvitelli, Dept Adv Med & Surg Sci, Piazza Luigi Miraglia 2, I-80138 Naples, NA, Italy

[4] Umberto I Hosp, Cardiol Unit, I-84014 Nocera Inferiore, SA, Italy

来源：

LIFE-BASEL | 2023年 / 13卷 / 09期

关键词：

malignancy; cancer; thrombosis; anticoagulants; inflammation; low-molecular-weight heparins; direct oral anticoagulants; PROTEASE-ACTIVATED RECEPTORS; ANTAGONIST ORAL ANTICOAGULANTS; COAGULATION-FACTOR-XA; MOLECULAR-WEIGHT HEPARIN; ATRIAL-FIBRILLATION; VENOUS THROMBOEMBOLISM; ENDOTHELIAL-CELLS; INFLAMMATORY REACTIONS; DABIGATRAN ETEXILATE; TUMOR PROGRESSION;

D O I：

10.3390/life13091888

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Optimizing the anticoagulation therapy is of pivotal importance in patients with a malignant tumor, as venous thromboembolism (VTE) has become the second-leading cause of death in this population. Cancer can highly increase the risk of thrombosis and bleeding. Consequently, the management of cancer-associated VTE is complex. In recent years, translational research has intensified, and several studies have highlighted the role of inflammatory cytokines in cancer growth and progression. Simultaneously, the pleiotropic effects of anticoagulants currently recommended for VTE have emerged. In this review, we describe the anti-inflammatory and anticancer effects of both direct oral anticoagulants (DOACs) and low-molecular-weight heparins (LWMHs).

引用

页数：19

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