Effect of platelet-rich plasma versus triamcinolone acetonide as adjuvant therapy to surgical excision of keloid

BackgroundKeloids are a cause of functional and aesthetic disfigurement. There are multiple treatment modalities. In this study, we did a comparison between the effect of platelet-rich plasma (PRP) and triamcinolone acetonide as an adjuvant to surgical excision of keloid. We aimed to compare the effect of PRP versus triamcinolone acetonide after surgical excision of the keloids in a group of randomized patients in terms of clinical improvement, recurrence, and patient satisfaction. MethodsBetween April 2019 to November 2020, we divided a total of 30 patients into two groups in whom surgical excision and closure of keloid were done, followed by injection of PRP (group A) and injection triamcinolone acetonide (group B) as adjuvant into the wound bed intraoperatively and then monthly for 3 months. They were followed up for a period of 6 months, and scar quality, patient satisfaction, and recurrence of keloid were analysed. ResultsSignificant improvement was seen in the vancouver scar scale (VSS) in all patients. The mean preoperative VSS of group A and group B patients was similar [7.87 +/- 1.60 and 7.47 +/- 1.36, respectively (p = 0.633)]. The mean postoperative VSS at the end of 6 months in group A and group B patients was 3.20 +/- 1.93 and 1.80 +/- 1.08, respectively (p = 0.031). Hence, the improvement in scar quality was better in group B. The recurrence of keloid was less in group B patients (p = 0.031). ConclusionsInjection Triamcinolone acetonide as an adjuvant following surgical excision of keloids gives better scar quality as compared to the injection PRP with lesser recurrence. Level of evidence: Level II, therapeutic study.