The potential role of miRNAs in the pathogenesis of adrenocortical carcinoma - A focus on signaling pathways interplay

被引：22

作者：

Midan, Heba M. ^{[1
]}

Helal, Gouda Kamel ^{[2
,3
]}

Abulsoud, Ahmed I. ^{[4
,5
]}

Elshaer, Shereen Saeid ^{[5
,6
]}

El-Husseiny, Ahmed A. ^{[4
,7
]}

Fathi, Doaa ^{[5
]}

Abdelmaksoud, Nourhan M. ^{[5
]}

Mageed, Sherif S. Abdel ^{[8
]}

Elballal, Mohammed S. ^{[1
]}

Zaki, Mohamed Bakr ^{[9
]}

Abd-Elmawla, Mai A. ^{[10
]}

AL-Noshokaty, Tohada M. ^{[5
]}

Rizk, Nehal I. ^{[5
]}

Elrebehy, Mahmoud A. ^{[1
]}

El-Dakroury, Walaa A. ^{[11
]}

Hashem, Amr H. ^{[12
]}

Doghish, Ahmed S. ^{[1
,4
]}

机构：

[1] Badr Univ Cairo BUC, Fac Pharm, Dept Biochem, Badr City 11829, Cairo, Egypt

[2] Al Azhar Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo 11231, Egypt

[3] Heliopolis Univ, Fac Pharm, Dept Pharmacol & Toxicol, Cairo 11785, Egypt

[4] Al Azhar Univ, Fac Pharm Boys, Biochem & Mol Biol Dept, Nasr City 11231, Cairo, Egypt

[5] Heliopolis Univ, Fac Pharm, Biochem Dept, Cairo 11785, Egypt

[6] Al Azhar Univ, Fac Pharm Girls, Dept Biochem, Nasr City 11823, Cairo, Egypt

[7] Egyptian Russian Univ, Fac Pharm, Dept Biochem, Badr City 11829, Cairo, Egypt

[8] Badr Univ Cairo BUC, Fac Pharm, Pharmacol & Toxicol Dept, Badr City 11829, Cairo, Egypt

[9] Univ Sadat City, Fac Pharm, Dept Biochem, Biochem, Menoufia 32897, Egypt

[10] Cairo Univ, Fac Pharm, Dept Biochem, Biochem, Cairo, Egypt

[11] Badr Univ Cairo BUC, Fac Pharm, Dept Pharmaceut & Ind Pharm, Badr City 11829, Cairo, Egypt

[12] Al Azhar Univ, Fac Sci, Bot & Microbiol Dept, Nasr City 11884, Cairo, Egypt

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2023年 / 248卷

关键词：

MiRNA; Adrenocortical carcinoma; ACC; Therapeutic intervention; Pathogenesis; Biomarker; ADRENAL-CORTICAL CARCINOMA; MICRORNA EXPRESSION; HEPATOCELLULAR-CARCINOMA; THERAPEUTIC TARGET; CLINICAL-FEATURES; BREAST-CANCER; TUMOR-CELLS; ALDOSTERONE; APOPTOSIS; SIGNATURE;

D O I：

10.1016/j.prp.2023.154690

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Adrenocortical carcinoma (ACC) is a highly malignant infrequent tumor with a dismal prognosis. microRNAs (miRNAs, miRs) are crucial in post-transcriptional gene expression regulation. Due to their ability to regulate multiple gene networks, miRNAs are central to the hallmarks of cancer, including sustained proliferative signaling, evasion of growth suppressors, resistance to cell death, replicative immortality, induction/access to the vasculature, activation of invasion and metastasis, reprogramming of cellular metabolism, and avoidance of immune destruction. ACC represents a singular form of neoplasia associated with aberrations in the expression of evolutionarily conserved short, non-coding RNAs. Recently, the role of miRNAs in ACC has been examined extensively despite the disease's rarity. Hence, the current review is a fast-intensive track elucidating the potential role of miRNAs in the pathogenesis of ACC besides their association with the survival of ACC.

引用

页数：14

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