A home-based lifestyle intervention program reduces the tumorigenic potential of triple-negative breast cancer cells

被引：0
|
作者：
Baldelli, Giulia [1 ]
Natalucci, Valentina [2 ]
Marini, Carlo Ferri [2 ]
Sisti, Davide [1 ]
Annibalini, Giosue [2 ]
Saltarelli, Roberta [2 ]
Bocconcelli, Matteo [2 ]
Gentilini, Veronica [1 ]
Emili, Rita [3 ]
Rocchi, Marco Bruno Luigi [1 ]
Lucertini, Francesco [2 ]
Barbieri, Elena [2 ]
Brandi, Giorgio [1 ]
De Santi, Mauro [1 ]
机构：
[1] Univ Urbino Carlo Bo, Dept Biomol Sci, Unit Pharmacol & Hyg, I-61029 Urbino, Italy
[2] Univ Urbino Carlo Bo, Dept Biomol Sci, Div Exercise & Hlth Sci, I-61029 Urbino, Italy
[3] Hosp Santa Maria Della Misericordia Urbino, Med Oncol, I-61029 Urbino, Italy
来源：
SCIENTIFIC REPORTS | 2024年 / 14卷 / 01期
关键词：
GROWTH-FACTOR-I; PHYSICAL-ACTIVITY; LOW-FAT; IGF-I; EXERCISE; INSULIN; RISK; DIET; MECHANISMS; APOPTOSIS;
D O I：
10.1038/s41598-024-52065-9
中图分类号：
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号：
07 ; 0710 ; 09 ;
摘要：
Translational research for the evaluation of physical activity habits and lifestyle modifications based on nutrition and exercise has recently gained attention. In this study, we evaluated the effects of serum samples obtained before and after a 12-week home-based lifestyle intervention based on nutrition and exercise in breast cancer survivors in terms of modulation of the tumorigenic potential of breast cancer cells. The home-based lifestyle intervention proposed in this work consisted of educational counselling on exercise and nutritional behaviors and in 12 weeks of structured home-based exercise. Triple-negative breast cancer cell line MDA-MB-231 was cultured in semi-solid medium (3D culture) with sera collected before (PRE) and after (POST) the lifestyle intervention program. Spheroid formation was evaluated by counting cell colonies after 3 weeks of incubation. Results show a slight but significant reduction of spheroid formation induced by serum collected POST in comparison to those obtained PRE. Moreover, statistical analyses aimed to find physiologic and metabolic parameters associated with 3D cell proliferation revealed the proliferative inducer IGF-1 as the only predictor of cell tumorigenic potential. These results highlight the importance of lifestyle changes for cancer progression control in a tertiary prevention context. Translational research could offer a useful tool to identify metabolic and physiological changes induced by exercise and nutritional behaviors associated with cancer progression and recurrence risk.
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页数：9
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