Mitochondria Transplantation from Stem Cells for Mitigating Sarcopenia

被引：6

作者：

Tian, Xiulin ^{[1
]}

Pan, Mengxiong ^{[3
]}

Zhou, Mengting ^{[2
]}

Tang, Qiaomin ^{[1
]}

Chen, Miao ^{[4
]}

Hong, Wenwu ^{[5
]}

Zhao, Fangling ^{[2
]}

Liu, Kaiming ^{[2
]}

机构：

[1] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Nursing, Hangzhou, Peoples R China

[2] Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurol, Hangzhou 310003, Zhejiang, Peoples R China

[3] First Peoples Hosp Huzhou, Dept Neurol, Huzhou, Zhejiang, Peoples R China

[4] Shaoxing Univ, Dept Neurol, Zhuji Affiliated Hosp, Zhuji, Zhejiang, Peoples R China

[5] Tiantai Peoples Hosp Zhejiang Prov, Dept Neurol, Taizhou, Zhejiang, Peoples R China

来源：

AGING AND DISEASE | 2023年 / 14卷 / 05期

基金：

中国国家自然科学基金;

关键词：

mitochondria; sarcopenia; stem cells; mitochondria quality control; MULTIPOTENT STROMAL CELLS; TUNNELING NANOTUBES; IN-VITRO; ENDOTHELIAL-CELLS; OXIDATIVE STRESS; MUSCLE; CARDIOMYOCYTES; MITOPHAGY; NEURONS; DYSFUNCTION;

D O I：

10.14336/AD.2023.0210

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Sarcopenia is defined as the age-related loss of muscle mass and function that can lead to prolonged hospital stays and decreased independence. It is a significant health and financial burden for individuals, families, and society as a whole. The accumulation of damaged mitochondria in skeletal muscle contributes to the degeneration of muscles with age. Currently, the treatment of sarcopenia is limited to improving nutrition and physical activity. Studying effective methods to alleviate and treat sarcopenia to improve the quality of life and lifespan of older people is a growing area of interest in geriatric medicine. Therapies targeting mitochondria and restoring mitochondrial function are promising treatment strategies. This article provides an overview of stem cell transplantation for sarcopenia, including the mitochondrial delivery pathway and the protective role of stem cells. It also highlights recent advances in preclinical and clinical research on sarcopenia and presents a new treatment method involving stem cell-derived mitochondrial transplantation, outlining its advantages and challenges.

引用

页码：1700 / 1713

页数：14

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