The Impact of Recombinant Human Erythropoietin Administration in Critically ill COVID-19 Patients: A Multicenter Cohort Study

被引：2

作者：

Al Sulaiman, Khalid ^{[1
,2
,3
,4
,19
]}

Aljuhani, Ohoud ^{[5
]}

Korayem, Ghazwa B. ^{[6
]}

Altebainawi, Ali F. ^{[7
,8
]}

Vishwakarma, Ramesh ^{[9
]}

Alfaifi, Mashael ^{[10
]}

Alsohimi, Samiah ^{[11
,12
]}

Alrayes, Aljoharah ^{[6
]}

Albishi, Sara ^{[6
]}

Alqahtani, Reem ^{[6
]}

Alalawi, Mai ^{[13
,14
]}

Al Sulaihim, Ibrahim ^{[15
]}

Alanazi, Thamer A. ^{[16
]}

Alqahtani, Rahaf A. ^{[1
]}

Almagthali, Alaa ^{[12
]}

Jomah, Shahamah ^{[17
]}

Alshlowi, Areej ^{[18
]}

Alshammari, Tahani R. ^{[7
]}

Alzahrani, Shahad S. ^{[2
]}

Abdulqader, Marwa I. ^{[2
]}

机构：

[1] King Abdul Aziz Med City, Pharmaceut Care Dept, Riyadh, Saudi Arabia

[2] King Saud Bin Abdulaziz Univ Hlth Sci, Coll Pharm, Riyadh, Saudi Arabia

[3] King Abdullah Int Med Res Ctr, =, Riyadh, Saudi Arabia

[4] Saudi Crit Care Pharm Res SCAPE Platform, Riyadh, Saudi Arabia

[5] King Abdulaziz Univ, Fac Pharm, Dept Pharm Practice, Jeddah, Saudi Arabia

[6] Princess Nourah Bint Abdulrahman Univ, Coll Pharm, Dept Pharm Practice, Riyadh, Saudi Arabia

[7] King Salman Specialist Hosp, Pharmaceut Care Serv, Hail Hlth Cluster, Minist Hlth, Hail, Saudi Arabia

[8] Univ Hail, Coll Pharm, Dept Clin Pharm, Hail, Saudi Arabia

[9] Univ East Anglia, Norwich Med Sch, Norwich, England

[10] King Saud Med City, Pharmaceut Care Dept, Riyadh, Saudi Arabia

[11] King Fahad Armed Forces Hosp, Pharmaceut Care Serv, Jeddah, Saudi Arabia

[12] King Abdulaziz Univ Hosp, Pharmaceut Care Serv, Jeddah, Saudi Arabia

[13] Fakeeh Coll Med Sci, Dept Pharmaceut Sci, Jeddah, Saudi Arabia

[14] King Abdul Aziz Med City, Pharmaceut Care Dept, Presidency State Secur, Jeddah, Saudi Arabia

[15] Cent Secur Hosp, Pharmaceut Care Dept, Presidency State Secur, Riyadh, Saudi Arabia

[16] King Abdul Aziz Med City, Resp Therapy Dept, Riyadh, Saudi Arabia

[17] Dr Sulaiman Al Habib Med Grp, Pharmaceut Care Dept, Riyadh, Saudi Arabia

[18] Almaarefa Univ, Coll Pharm, Dept Pharm Practice, Riyadh, Saudi Arabia

[19] King Saud Bin Abdulaziz Univ Hlth Sci, King Abdulaziz Med City KAMC, Minist Natl Guard Hlth Affairs MNGHA, King Abdullah Int Med Res Ctr, POB 22490, Riyadh 11426, Saudi Arabia

来源：

CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS | 2023年 / 29卷

关键词：

critically ill; COVID-19; erythropoietin-stimulating agents; ESA; length of stay; mortality; ventilator-free days (VFDs); MODEL;

D O I：

10.1177/10760296231218216

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The use of erythropoietin-stimulating agents (ESAs) as adjunctive therapy in critically ill patients with COVID-19 may have a potential benefit. This study aims to evaluate the effect of ESAs on the clinical outcomes of critically ill COVID-19 patients. A multicenter, retrospective cohort study was conducted from 01-03-2020 to 31-07-2021. We included adult patients who were >= 18 years old with a confirmed diagnosis of COVID-19 infection and admitted to intensive care units (ICUs). Patients were categorized depending on ESAs administration during their ICU stay. The primary endpoint was the length of stay; other endpoints were considered secondary. After propensity score matching (1:3), the overall included patients were 120. Among those, 30 patients received ESAs. A longer duration of ICU and hospital stay was observed in the ESA group (beta coefficient: 0.64; 95% CI: 0.31-0.97; P = < .01, beta coefficient: 0.41; 95% CI: 0.12-0.69; P = < .01, respectively). In addition, the ESA group's ventilator-free days (VFDs) were significantly shorter than the control group. Moreover, patients who received ESAs have higher odds of liver injury and infections during ICU stay than the control group. The use of ESAs in COVID-19 critically ill patients was associated with longer hospital and ICU stays, with no survival benefits but linked with lower VFDs.

引用

页数：10

共 50 条

[1] The Impact of Recombinant Human Erythropoietin Administration in Critically ill COVID-19 Patients: A Multicenter Cohort Study
Al Sulaiman, Khalid
Aljuhani, Ohoud
Korayem, Ghazwa B.
Altebainawi, Ali F.
Vishwakarma, Ramesh
AlFaifi, Mashael
Alsohimi, Samiah
Alrayes, Aljoharah
Albishi, Sara
Alqahtani, Reem
Alalawi, Mai
Al Sulaihim, Ibrahim
Alanazi, Thamer A.
Alqahtani, Rahaf A.
Almagthali, Alaa
Jomah, Shahamah
Alshlowi, Areej
Alshammari, Tahani R.
Alzahrani, Shahad S.
Abdulqader, Marwa I.
[J]. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2023, 29
[2] Does recombinant human erythropoietin administration in critically ill COVID-19 patients have miraculous therapeutic effects?
Hadadi, Azar
Mortezazadeh, Masoud
Kolahdouzan, Kasra
Alavian, Golbarg
[J]. JOURNAL OF MEDICAL VIROLOGY, 2020, 92 (07) : 915 - 918
[3] Statins and Risk of Thrombosis in Critically ill Patients with COVID-19: A Multicenter Cohort Study
Al Harbi, Shmeylan
Kensara, Raed
Aljuhani, Ohoud
Korayem, Ghazwa B.
Altebainawi, Ali F.
Al Harthi, Abdullah
Vishwakarma, Ramesh
Alenazi, Alaa M.
Almutairi, Abdulmajed
Alshaya, Omar
Alraddadi, Sultan
Al Sulaiman, Tareq
Aldakkan, Latifah
Mahboob, Reem
Alaamer, Kholoud
Alissa, Abdulrahman
Hafiz, Awatif
Aldhayyan, Nada
Althewaibi, Sara
Alenezi, Farhan
Alkhotani, Nadeen Y.
Alghamdi, Sara A.
Alenazi, Abeer A.
Al Sulaiman, Khalid
[J]. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2022, 28
[4] Statins and Risk of Thrombosis in Critically ill Patients with COVID-19: A Multicenter Cohort Study
Al Harbi, Shmeylan
Kensara, Raed
Aljuhani, Ohoud
Korayem, Ghazwa B.
Altebainawi, Ali F.
Al Harthi, Abdullah
Vishwakarma, Ramesh
Alenazi, Alaa M.
Almutairi, Abdulmajed
Alshaya, Omar
Alraddadi, Sultan
Al Sulaiman, Tareq
Aldakkan, Latifah
Mahboob, Reem
Alaamer, Kholoud
Alissa, Abdulrahman
Hafiz, Awatif
Aldhayyan, Nada
Althewaibi, Sara
Alenezi, Farhan
Alkhotani, Nadeen Y.
Alghamdi, Sara A.
Alenazi, Abeer A.
Al Sulaiman, Khalid
[J]. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2022, 28
[5] Statins and Risk of Thrombosis in Critically ill Patients with COVID-19: A Multicenter Cohort Study
Al Harbi, Shmeylan
Kensara, Raed
Aljuhani, Ohoud
Korayem, Ghazwa B.
Altebainawi, Ali F.
Al Harthi, Abdullah
Vishwakarma, Ramesh
Alenazi, Alaa M.
Almutairi, Abdulmajed
Alshaya, Omar
Alraddadi, Sultan
Al Sulaiman, Tareq
Aldakkan, Latifah
Mahboob, Reem
Alaamer, Kholoud
Alissa, Abdulrahman
Hafiz, Awatif
Aldhayyan, Nada
Althewaibi, Sara
Alenezi, Farhan
Alkhotani, Nadeen Y.
Alghamdi, Sara A.
Alenazi, Abeer A.
Al Sulaiman, Khalid
[J]. CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS, 2022, 28
[6] Association of BMI with Outcomes in Critically ill Patients with COVID-19: Multicenter Cohort Study
Pattou, Francois
Chetboun, Mikael
Raverdy, Violeta
Jourdain, Merce
[J]. OBESITY, 2020, 28 : 8 - 8
[7] IMPACT OF STATINS ON THE CLINICAL OUTCOMES IN COVID-19 CRITICALLY ILL PATIENTS: A MULTICENTER STUDY
Alsulaiman, Khalid
Aljuhani, Ohoud
Korayem, Ghazwa B.
Altebainawi, Ali
Al Shaya, Abdulrahman
Badreldin, Hisham
Al Harthi, Abdullah
Alissa, Abdulrahman
Vishwakarma, Ramesh
Kensara, Raed
[J]. CRITICAL CARE MEDICINE, 2022, 50 (01) : 84 - 84
[8] Palliative Care in a Pandemic: A Multicenter Cohort of Critically Ill COVID-19 Patients
Kodadek, Lisa M.
Moore, Miranda S.
Miller, Samuel
Schneider, Eric
Ahuja, Vanita
Maerz, Linda
Davis, Kimberly A.
[J]. JOURNAL OF THE AMERICAN COLLEGE OF SURGEONS, 2022, 235 (05) : S38 - S38
[9] In-hospital cardiac arrest in critically ill patients with covid-19: multicenter cohort study
Hayek, Salim S.
Brenner, Samantha K.
Azam, Tariq U.
Shadid, Husam R.
Anderson, Elizabeth
Berlin, Hanna
Pan, Michael
Meloche, Chelsea
Feroz, Rafey
O'Hayer, Patrick
Kaakati, Rayan
Bitar, Abbas
Padalia, Kishan
Perry, Daniel
Blakely, Pennelope
Gupta, Shruti
Shaefi, Shahzad
Srivastava, Anand
Charytan, David M.
Bansal, Anip
Mallappallil, Mary
Melamed, Michal L.
Shehata, Alexandre M.
Sunderram, Jag
Mathews, Kusum S.
Sutherland, Anne K.
Nallamothu, Brahmajee K.
Leaf, David E.
[J]. BMJ-BRITISH MEDICAL JOURNAL, 2020, 371 : m3513
[10] The use of Tocilizumab in COVID-19 critically ill patients with renal impairment: a multicenter, cohort study
Aljuhani, Ohoud
Al Sulaiman, Khalid
Korayem, Ghazwa
Alharbi, Aisha
Altebainawi, Ali F.
Aldkheel, Shatha A.
Alotaibi, Sarah G.
Vishwakarma, Ramesh
Alshareef, Hanan
Alsohimi, Samiah
AlFaifi, Mashael
Al Shaya, Abdulrahman
Alhaidal, Haifa A.
Alsubaie, Raghad M.
Alrashidi, Hessah
Albarqi, Khalid J.
Alangari, Dalal T.
Alanazi, Reem M.
Altaher, Noora M.
Al-Dorzi, Hasan M.
[J]. RENAL FAILURE, 2023, 45 (02)

← 1 2 3 4 5 →