Synthesis and antinociceptive activity of N-substituted 4-aryl-2-[(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino]4-oxobut-2-enamides

被引：5
|
作者：
Gorbunova, I. A. [1 ,2 ]
Okoneshnikova, E. A. [1 ,2 ]
Makhmudov, R. R. [1 ]
Shipilovskikh, D. A. [1 ,3 ]
Shadrin, V. M. [1 ,4 ]
Silaichev, P. S. [1 ]
Shipilovskikh, S. A. [1 ,2 ]
机构：
[1] Perm State Natl Res Univ, 15 Ul Bukireva, Perm 614990, Russia
[2] Univ ITMO, Sch Phys & Engn, Build A,49 Kronverksky prosp, St Petersburg 197101, Russia
[3] Perm Natl Res Polytech Univ, 29 Komsomolsky Prosp, Perm 614990, Russia
[4] Minist Hlth Russian Federat, Perm State Pharmaceut Acad, 101 ul Ekaterininskaya, Perm 614990, Russia
来源：
RUSSIAN CHEMICAL BULLETIN | 2023年 / 72卷 / 08期
关键词：
Gewald thiophenes; 2,4-dioxobutanoic acids; 3-iminofuran-2(3H)-ones; antinociceptive activity; toxicity; ANTIBACTERIAL ACTIVITY; ANALGESIC ACTIVITY; INTRAMOLECULAR CYCLIZATION; ANTIMICROBIAL ACTIVITY; BIOLOGICAL EVALUATION; ARYLDIKETO ACIDS; DERIVATIVES; DECYCLIZATION; DOCKING; DESIGN;
D O I：
10.1007/s11172-023-3975-y
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
N-Substituted 4-aryl-2-[(3-cyano-4,5,6,7-tetrahydrobenzo[b]thiophen-2-yl)amino]-4-oxobut-2-enamides were synthesized by the reaction of 2-[(5-aryl-2-oxofuran-3(2H)-ylidene)amino]-4,5,6,7-tetrahydrobenzo[b]thiophene-3-carbonitriles with primary amines. The synthesized compounds are non-toxic and have pronounced antinociceptive activity.
引用
收藏
页码：1905 / 1912
页数：8
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