A silyl porphyrin derivative conjugated with 6-deoxy-6-sulfo-α-D-glucopyranose functions as an efficient photosensitizer for photodynamic therapy

被引：0
|
作者：
Horiuchi, Hiroaki [1 ]
Nishikawa, Kota [1 ]
Ishii, Nozomi [1 ]
Kano, Koki [1 ]
Shinada, Shunsuke [2 ]
Osawa, Nene [1 ]
Horikoshi, Aoi [1 ]
Yoshihara, Toshitada [1 ]
Sugawara, Fumio [3 ]
Sakaguchi, Kengo [3 ]
Okustu, Tetsuo [1 ]
Katsura, Shinji [2 ,4 ]
Matsuo, Ichiro [1 ]
Oshige, Masahiko [2 ,4 ]
机构：
[1] Gunma Univ, Grad Sch Sci & Technol, Div Mol Sci, Kiryu, Gunma 3768515, Japan
[2] Gunma Univ, Grad Sch Sci & Technol, Dept Environm Engn Sci, Kiryu, Gunma 3768515, Japan
[3] Tokyo Univ Sci, Fac Sci & Technol, Dept Appl Biol Sci, Noda, Chiba 2788510, Japan
[4] Gunma Univ Ctr Food Sci & Wellness GUCFW, Maebashi, Gunma 3718510, Japan
来源：
PHOTODIAGNOSIS AND PHOTODYNAMIC THERAPY | 2024年 / 45卷
基金：
日本学术振兴会;
关键词：
Silyl porphyrin; Photodynamic therapy; Photosensitizer; 6-deoxy-6-sulfo-alpha-D-glucopyranose; PHOTOPHYSICAL PROPERTIES; TETRAPHENYLPORPHYRIN; OXYGEN; ENHANCEMENT; IMPROVES;
D O I：
10.1016/j.pdpdt.2023.103898
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
We synthesized a new silyl porphyrin derivative conjugated with 6-deoxy-6-sulfo-alpha-d-glucopyranose (SGlc). Conjugation with SGlc improved A549 cellular uptake without significant changes in the photophysical and photochemical properties and subcellular localization. This improved cellular uptake led to enhanced photodynamic activity. Furthermore, conjugation with SGlc suppressed dark toxicity. These advantages were not observed for a conjugate with a glucose molecule. These results indicated that the conjugation with SGlc is a promising strategy for enhancing photodynamic efficacy.
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页数：7
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