Synthesis and Antiproliferative Properties of Some Spirocyclic Pyrimidine Hydrazones

A new series of hydrazone derivatives incorporating spirocyclic aminopyrimidine with aryl alkanesulfonates were synthesized. The targeted products were obtained in excellent yields via an acid catalyzed reaction of spirocyclic hydrazinopyrimidine with aryl aldehyde sulfonates. The structures of the synthesized hydrazones were studied by the different spectroscopic tools, in addition to the high resolution mass analysis. The antiproliferative activities of the compounds were tested in vitro against the National Cancer Institute (NCI) 60 cell panel by the Developmental Therapeutics Program. Amongst the tested hydrazone compounds, the methansulfonate derivatives showed the highest activities against lung, brain, kidney, and breast cancers. A new series of hydrazone derivatives 4 a-l incorporating spirocyclic pyrimidine with aryl alkanesulfonates were synthesized, and their antiproliferative activities were tested in vitro against NCI-60 cell panel. Three compounds showed good activities against different kinds of cancers. image