Intensive Weight-Loss Lifestyle Intervention Using Mediterranean Diet and COVID-19 Risk in Older Adults: Secondary Analysis of PREDIMED-Plus Trial

被引：1

作者：

Shyam, Sangeetha ^{[1
,2
,3
,38
]}

Garcia-Gavilan, J. F. ^{[1
,2
,3
]}

Paz-Graniel, I. ^{[1
,2
,3
]}

Gaforio, J. J. ^{[4
,5
]}

Martinez-Gonzalez, M. A.

Corella, D. ^{[1
,7
]}

Martinez, J. A. ^{[8
,9
,10
]}

Alonso-Gomez, A. M. ^{[1
,11
]}

Warnberg, J. ^{[1
,12
]}

Vioque, J. ^{[4
,13
]}

Romaguera, D. ^{[1
,14
]}

Lopez-Miranda, J. ^{[1
,15
]}

Estruch, R. ^{[1
,16
,17
]}

Tinahones, F. J. ^{[1
,18
]}

Lapetra, J. ^{[1
,19
]}

Serra-Majem, J. L. ^{[1
,20
,21
]}

Bueno-Cavanillas, A.

Tur, J. A. ^{[1
,23
]}

Sanchez, V. Martin ^{[4
,24
]}

Pinto, X. ^{[1
,25
]}

Matia-Martin, P.

Vidal, J. ^{[26
,27
]}

Alcarria, M. Del Mar ^{[28
]}

Daimiel, L. ^{[1
,29
,30
]}

Ros, E. ^{[1
,31
]}

Fernandez-Aranda, F. ^{[32
]}

Nishi, S. K. ^{[1
,2
,3
,33
]}

Garcia-Regata, O.

Araluce, R. Perez ^{[6
]}

Asensio, E. M. ^{[1
,7
]}

Castaner, O. ^{[4
,34
]}

Garcia-Rios, A. ^{[1
,15
]}

Oncina-Canovas, A.

Bouzas, C. ^{[23
]}

Zulet, M. A. ^{[1
,8
]}

Rayo, E. ^{[14
]}

Casas, R. ^{[1
,16
,17
]}

Martin-pelaez, S. ^{[4
,22
]}

Tojal-Sierra, L. ^{[1
,11
]}

Bernal-Lopez, M. R.

Carlos, S. ^{[6
]}

Sorli, J. V. ^{[1
,7
]}

Goday, A. ^{[1
,34
]}

Pena-Orihuela, P. J. ^{[1
,15
]}

Pastor-Morel, A. ^{[35
]}

Eguaras, S. ^{[6
]}

Zomeno, M. D. ^{[1
,34
,36
]}

Delgado-Rodriguez, M. ^{[1
,9
,10
,37
]}

Babio, N. ^{[1
,2
,3
]}

Fito, M. ^{[1
,34
]}

机构：

[1] Inst Salud Carlos III, CIBER Fisiopatol Obesidad & Nutr CIBERObn, Madrid, Spain

[2] Univ Rovira I Virgili, Dept Bioquim & Biotecnol, Grup Alimentacio Nutr Desenvolupament & Salut Ment, Unitat Nutr Humana, Reus, Spain

[3] Inst Invest Sanitaria Pere Virgili IISPV, Reus, Spain

[4] Inst Salud Carlos III ISCIII, CIBER Epidemiol & Salud Publ CIBERESP, Madrid, Spain

[5] Univ Jaen, Inst Univ Invest Olivar & Aceites Oliva, Dept Ciencias Salud, Jaen, Spain

[6] Univ Navarra, Dept Prevent Med & Publ Hlth, Inst Invest Sanitaria Navarra IdiSNA, Pamplona, Spain

[7] Univ Valencia, Dept Prevent Med, Valencia, Spain

[8] Univ Navarra, Ctr Nutr Res, Dept Nutr Food Sci & Physiol, Pamplona, Spain

[9] IMDEA Alimentac, Precis Nutr & Cardiometab Hlth Program, Madrid, Spain

[10] UVA, Med & Endocrinol, Valladolid, Spain

[11] Univ Basque Country UPV EHU, Araba Univ Hosp, Dept Internal Med, Vitoria, Spain

[12] Univ Malaga, Sch Hlth Sci, EpiPHAAN Res Grp, Inst Invest Biomed Malaga IBIMA, Malaga, Spain

[13] Univ Miguel Hernandez ISABIAL UMH, Inst Invest Sanitaria & Biomed Alicante, Alicante, Spain

[14] Hlth Res Inst Balear Isl IdISBa, Palma De Mallorca, Spain

[15] Univ Cordoba, Reina Sofia Univ Hosp, Maimonides Biomed Res Inst Cordoba IMIBIC, Dept Internal Med, Cordoba, Spain

[16] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi & Sunyer IDIBAPS, Dept Internal Med, Barcelona, Spain

[17] Univ Barcelona, Inst Recerca Nutr & Seguretat Alimentaria INSA UB, Barcelona, Spain

[18] Univ Malaga, Virgen Victoria Hosp, Dept Endocrinol, Inst Invest Biomed Malaga IBIMA, Malaga, Spain

[19] Dist Sanitario Atenc Primaria Sevilla, Dept Family Med, Res Unit, Seville, Spain

[20] Univ Las Palmas Gran Canaria, Res Inst Biomed & Hlth Sci IUIBS, Canarian Hlth Serv, Las Palmas Gran Canaria, Spain

[21] Ctr Hosp Univ Insular Materno Infantil CHUIMI, Canarian Hlth Serv, Las Palmas Gran Canaria, Spain

[22] Univ Granada, Dept Prevent Med & Publ Hlth, Granada, Spain

[23] Univ Balear Isl, Res Grp Community Nutr & Oxidat Stress, Palma De Mallorca, Spain

[24] Univ Leon, Inst Biomed IBIOMED, Leon, Spain

[25] Hosp Univ Bellvitge, Lipids & Vasc Risk Unit, Internal Med, IDIBELL, Barcelona, Spain

[26] Inst Salud Carlos III ISCIII, CIBER Diabet & Enfermedades Metab CIBERDEM, Madrid, Spain

[27] Univ Barcelona, Hosp Clin, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol, Barcelona, Spain

[28] Univ Autonoma, Hosp Fdn Jimenez Diaz, Dept Endocrinol & Nutr, Inst Invest Biomed IISFJD, Madrid, Spain

[29] CEI UAM CSIC, Obes Program, Nutr Control Epigenome Grp Precis Nutr, IMDEA Food, Madrid, Spain

[30] Univ San Pablo CEU, Dept Ciencias Farmaceut & Salud, Fac Farm, CEU Univ, Boadilla Del Monte, Spain

[31] Hosp Clin Barcelona, Inst Invest Biomed August Pi Sunyer IDIBAPS, Dept Endocrinol & Nutr, Lipid Clin, Barcelona, Spain

[32] Univ Barcelona, Barcelona, Spain

[33] St Michaels Hosp, Clin Nutr & Risk Factor Modificat Ctr, Toronto Diet Digest Tract & Dis Knowledge Synth &, Unity Hlth Toronto, Toronto, ON, Canada

[34] Inst Hosp Mar Invest Med Municipal Invest Med IMIM, Unit Cardiovasc Risk & Nutr, Barcelona, Spain

[35] Ctr Salud Cabo Huertas, Alicante, Spain

[36] Blanquerna Ramon Llull Univ, Barcelona, Spain

[37] Univ Jaen, Fac Med, Div Prevent Med, Jaen, Spain

[38] Univ Rovira I Virgili, Dept Bioquim & Biotecnol, Human Nutr Unit, Food Nutr Dev & Mental Hlth Grp ANUT DSM, C Sant Llorenc 21, Reus 43201, Spain

来源：

JOURNAL OF NUTRITION HEALTH & AGING | 2023年 / 27卷 / 12期

关键词：

COVID-19; SARS-CoV2; PREDIMED-Plus; Mediterranean diet; Older adults;

D O I：

10.1007/s12603-023-2044-4

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

ObjectivesWe tested the effects of a weight-loss intervention encouraging energy-reduced MedDiet and physical activity (PA) in comparison to ad libitum MedDiet on COVID-19 incidence in older adults.DesignSecondary analysis of PREDIMED-Plus, a prospective, ongoing, multicentre randomized controlled trial.SettingCommunity-dwelling, free-living participants in PREDIMED-Plus trial.Participants6,874 Spanish older adults (55-75 years, 49% women) with overweight/obesity and metabolic syndrome.InterventionParticipants were randomised to Intervention (IG) or Control (CG) Group. IG received intensive behavioural intervention for weight loss with an energy-reduced MedDiet intervention and PA promotion. CG was encouraged to consume ad libitum MedDiet without PA recommendations.MeasurementsCOVID-19 was ascertained by an independent Event Committee until December 31, 2021. COX regression models compared the effect of PREDIMED-Plus interventions on COVID-19 risk.ResultsOverall, 653 COVID-19 incident cases were documented (IG:317; CG:336) over a median (IQR) follow-up of 5.8 (1.3) years (inclusive of 4.0 (1.2) years before community transmission of COVID-19) in both groups. A significantly lowered risk of COVID-19 incidence was not evident in IG, compared to CG (fully-adjusted HR (95% CI): 0.96 (0.81,1.12)).ConclusionsThere was no evidence to show that an intensive weight-loss intervention encouraging energy-reduced MedDiet and PA significantly lowered COVID-19 risk in older adults with overweight/ obesity and metabolic syndrome in comparison to ad libitum MedDiet. Recommendations to improve adherence to MedDiet provided with or without lifestyle modification suggestions for weight loss may have similar effects in protecting against COVID-19 risk in older adults with high cardiovascular risks.

引用

页码：1153 / 1161

页数：9

共 34 条

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Sangeetha Shyam
J. F. García-Gavilán
I. Paz-Graniel
J. J. Gaforio
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J. Wärnberg
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J. Lapetra
J. L. Serra-Majem
A. Bueno-Cavanillas
J. A. Tur
V. Martín Sánchez
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P. Matía-Martín
J. Vidal
M. del Mar Alcarria
L. Daimiel
E. Ros
F. Fernandez-Aranda
S. K. Nishi
Ó. García-Regata
R. Perez Araluce
E. M. Asensio
O. Castañer
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C. Bouzas
M. A. Zulet
E. Rayó
R. Casas
S. Martin-Pelaez
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M. R. Bernal-López
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J. V. Sorlí
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P. J. Peña-Orihuela
A. Pastor-Morel
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N. Babio
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