Results from a first-in-human phase I study of F182112, a B-cell maturation antigen (BCMA)-CD3 bispecific antibody, in patients with relapsed/refractory multiple myeloma.

被引：0
|
作者：
Sun, Mingyuan
Qiu, Lugui
Wei, Yongqiang
Jin, Jie
Li, Xin
Liu, Xue
Yin, Shaohong
Qi, Junyuan
机构：
[1] Natl Clin Res Ctr Hematol Disorders, Inst Hematol & Blood Dis Hosp, State Key Lab Expt Hematol, Tianjin, Peoples R China
[2] Chinese Acad Med Sci & Peking Union Med Co, Inst Hematol, State Key Lab Expt Hematol, Tianjin, Peoples R China
[3] Chinese Acad Med Sci & Peking Union Med Co, Blood Dis Hosp, Tianjin, Peoples R China
[4] Southern Med Univ, Nanfang Hosp, Guangzhou, Peoples R China
[5] Zhejiang Univ, Affiliated Hosp 1, Coll Med, Hangzhou, Zhejiang, Peoples R China
[6] Cent South Univ, Xiangya Hosp 3, Dept Hematol, Changsha, Peoples R China
[7] Lunan Pharmaceut Grp Co LTD, Linyi, Shandong, Peoples R China
[8] Chinese Acad Med Sci, Blood Inst, Tianjin, Peoples R China
来源：
JOURNAL OF CLINICAL ONCOLOGY | 2023年 / 41卷 / 16期
关键词：
D O I：
暂无
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
8038
引用
收藏
页数：1
相关论文
共 50 条
  • [1] A Phase 1 First-in-Human Monotherapy Study of F182112, a B-Cell Maturation Antigen (BCMA)-CD3 Bispecific Antibody, in Patients with Relapsed or Refractory Multiple Myeloma
    Sun, Mingyuan
    Qi, Junyuan
    Qiu, Lugui
    Jin, Jie
    Li, Xin
    Wei, Yongqiang
    Zhang, Guimin
    Liu, Xue
    Yin, Shaohong
    BLOOD, 2023, 142
  • [2] Updated phase 1 results of teclistamab, a B-cell maturation antigen (BCMA) x CD3 bispecific antibody, in relapsed/refractory multiple myeloma (MM).
    Krishnan, Amrita Y.
    Garfall, Alfred L.
    Mateos, Maria-Victoria
    van de Donk, Niels W. C. J.
    Nahi, Hareth
    San-Miguel, Jesus F.
    Oriol, Albert
    Rosinol, Laura
    Chari, Ajai
    Bhutani, Manisha
    Karlin, Lionel
    Benboubker, Lotfi
    Pei, Lixia
    Verona, Raluca
    Girgis, Suzette
    Stephenson, Tara
    Goldberg, Jenna D.
    Banerjee, Arnob
    Usmani, Saad Zafar
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [3] Updated Phase 1 Results of Teclistamab, a B-Cell Maturation Antigen (BCMA) x CD3 Bispecific Antibody, in Relapsed and/or Refractory Multiple Myeloma (RRMM)
    Garfall, Alfred L.
    Usmani, Saad Z.
    Mateos, Maria-Victoria
    Nahi, Hareth
    van de Donk, Niels W. C. J.
    San-Miguel, Jesus F.
    Rocafiguera, Albert Oriol
    Rosinol, Laura
    Chari, Ajai
    Bhutani, Manisha
    Pei, Lixia
    Verona, Raluca
    Girgis, Suzette
    Stephenson, Tara
    Goldberg, Jenna D.
    Banerjee, Arnob
    Krishnan, Amrita
    BLOOD, 2020, 136
  • [4] A Phase I First-in-Human Study of ABBV-383, a B-Cell Maturation Antigen x CD3 Bispecific T-Cell Redirecting Antibody, in Patients With Relapsed/Refractory Multiple Myeloma
    D'Souza, Anita
    Shah, Nina
    Rodriguez, Cesar
    Voorhees, Peter M.
    Weisel, Katja
    Bueno, Orlando F.
    Pothacamury, Rajvineeth K.
    Freise, Kevin J.
    Yue, Susan
    Ross, Jeremy A.
    Polepally, Akshanth R.
    Talati, Chetasi
    Lee, Shane
    Jin, Ziyi
    Buelow, Ben
    Vij, Ravi
    Kumar, Shaji
    JOURNAL OF CLINICAL ONCOLOGY, 2022, 40 (31) : 3576 - +
  • [5] Phase I study of teclistamab, a humanized B-cell maturation antigen (BCMA) x CD3 bispecific antibody, in relapsed/refractory multiple myeloma (R/R MM).
    Usmani, Saad Zafar
    Mateos, Maria-Victoria
    Nahi, Hareth
    Krishnan, Amrita Y.
    van de Donk, Niels W. C. J.
    San Miguel, Jesus
    Oriol, Albert
    Rosinol, Laura
    Chari, Ajai
    Adams, Homer
    Girgis, Suzette
    Lin, Shun Xin Wang
    Stephenson, Tara
    Kemmerer, Kristy
    Smit, Jennifer
    Elsayed, Yusri A.
    Infante, Jeffrey R.
    Goldberg, Jenna D.
    Banerjee, Arnob
    Garfall, Alfred L.
    JOURNAL OF CLINICAL ONCOLOGY, 2020, 38 (15)
  • [6] Safety, Clinical Activity, Pharmacokinetics, and Pharmacodynamics from a Phase I Study of PF-06863135, a B-Cell Maturation Antigen (BCMA)-CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)
    Raje, Noopur S.
    Jakubowiak, Andrzej
    Gasparetto, Cristina
    Cornell, Robert F.
    Krupka, Heike I.
    Navarro, Daniel
    Forgie, Alison J.
    Udata, Chandrasekhar
    Basu, Cynthia
    Chou, Jeffrey
    Leung, Abraham
    Lesokhin, Alexander M.
    BLOOD, 2019, 134
  • [7] Efficacy and safety of elranatamab (PF-06863135), a B-cell maturation antigen (BCMA)-CD3 bispecific antibody, in patients with relapsed or refractory multiple myeloma (MM).
    Bahlis, Nizar J.
    Raje, Noopur S.
    Costello, Caitlin
    Dholaria, Bhagirathbhai R.
    Solh, Melhem M.
    Levy, Moshe Y.
    Tomasson, Michael H.
    Dube, Harman
    Liu, Feng
    Liao, Kai Hsin
    Basu, Cynthia
    Skoura, Athanasia
    Chan, Edward Michael
    Trudel, Suzanne
    Jakubowiak, Andrzej J.
    Chu, Michael P.
    Gasparetto, Cristina
    Dalovisio, Andrew
    Sebag, Michael
    Lesokhin, Alexander M.
    JOURNAL OF CLINICAL ONCOLOGY, 2021, 39 (15)
  • [8] A Phase I Study of RO7297089, a B-Cell Maturation Antigen (BCMA)-CD16a Bispecific Antibody in Patients with Relapsed/Refractory Multiple Myeloma (RRMM)
    Plesner, Torben
    Harrison, Simon J.
    Quach, Hang
    Lee, Cindy H.
    Bryant, Adam
    Vangsted, Annette Juul
    Estell, Jane
    Delforge, Michel
    Offner, Fritz
    Twomey, Patrick
    Choeurng, Voleak
    Li, Junyi
    Hendricks, Robert
    Sumiyoshi, Teiko
    Miller, Karen
    Choi, Eunpi
    Schjesvold, Fredrik H.
    BLOOD, 2021, 138
  • [9] A Phase 1 First-in-Human Study of Tnb-383B, a BCMA x CD3 Bispecific T-Cell Redirecting Antibody, in Patients with Relapsed/Refractory Multiple Myeloma
    Kumar, Shaji
    D'Souza, Anita
    Shah, Nina
    Rodriguez, Cesar
    Voorhees, Peter M.
    Bueno, Orlando F.
    Ben Buelow
    Freise, Kevin J.
    Yue, Susan
    Pothacamury, Rajvineeth Kumar
    Polepally, Akshanth R.
    Vij, Ravi
    BLOOD, 2021, 138
  • [10] Teclistamab, a B-Cell Maturation Antigen (BCMA) x CD3 Bispecific Antibody, in Patients with Relapsed/Refractory Multiple Myeloma (RRMM): Correlative Analyses from MajesTEC-1
    Cortes-Selva, Diana
    Casneuf, Tineke
    Vishwamitra, Deeksha
    Stein, Sarah
    Perova, Tatiana
    Skerget, Sheri
    Ramos, Elena
    van Steenbergen, Laure
    De Maeyer, Dries
    Boominathan, Rengasamy
    Lau, Onsay
    Davis, Cuc
    Banerjee, Arnob
    Stephenson, Tara
    Uhlar, Clarissa M.
    Kobos, Rachel
    Goldberg, Jenna D.
    Pei, Lixia
    Trancucci, Danielle
    Girgis, Suzette
    Lin, Shun Xin Wang
    Wu, Liviawati S.
    Moreau, Philippe
    Usmani, Saad
    Bahlis, Nizar Jacques
    Van de Donk, Niels W. C. J.
    Verona, Raluca
    BLOOD, 2022, 140
12345