Genetics of cannabis use in opioid use disorder: A genome-wide association and polygenic risk score study

被引:1
|
作者
Hillmer, Alannah [1 ]
Chawar, Caroul [1 ]
Lamri, Amel [2 ]
Hudson, Jacqueline [1 ]
Kapczinski, Flavio [3 ,4 ]
Minuzzi, Luciano [1 ]
Marsh, David C. [5 ]
Thabane, Lehana [6 ]
Paterson, Andrew D. [7 ,8 ]
Samaan, Zainab [1 ]
机构
[1] McMaster Univ, Dept Psychiat & Behav Neurosci, Hamilton, ON, Canada
[2] McMaster Univ, Dept Med, Hamilton, ON, Canada
[3] McMaster Univ, Hamilton, ON, Canada
[4] Univ Fed Rio Grande Sol, Porto Alegre, Brazil
[5] NOSM Univ, Sudbury, ON, Canada
[6] Dept Hlth Res Method Evidence & Impact, Hamilton, ON, Canada
[7] Univ Toronto, Hosp Sick Children, Dalla Lana Sch Publ Hlth, Program Genet & Genome Biol,Div Biostat, Toronto, ON, Canada
[8] Univ Toronto, Hosp Sick Children, Dalla Lana Sch Publ Hlth, Program Genet & Genome Biol,Div Epidemiol, Toronto, ON, Canada
来源
PLOS ONE | 2023年 / 18卷 / 07期
关键词
METHADONE-MAINTENANCE TREATMENT; METAANALYSIS; DATABASE; OUTCOMES;
D O I
10.1371/journal.pone.0289059
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
BackgroundIndividuals with an Opioid Use Disorder (OUD) have increased rates of cannabis use in comparison to the general population. Research on the short- and long-term impacts of cannabis use in OUD patients has been inconclusive. A genetic component may contribute to cannabis cravings. AimsIdentify genetic variants associated with cannabis use through Genome-wide Association Study (GWAS) methods and investigate a Polygenic Risk Score (PRS). In addition, we aim to identify any sex differences in effect size for genetic variants reaching or nearing genome-wide significance in the GWAS. MethodsThe study outcomes of interest were: regular cannabis use (yes/no) (n = 2616), heaviness of cannabis use (n = 1293) and cannabis cravings (n = 836). Logistic and linear regressions were preformed, respectively, to test the association between genetic variants and each outcome, regular cannabis use and heaviness of cannabis use. GWAS summary statistics from a recent large meta-GWAS investigating cannabis use disorder were used to conduct PRS's. Findings are limited to a European ancestry sample. ResultsNo genome-wide significant associations were found. Rs1813412 (chromosome 17) for regular cannabis use and rs62378502 (chromosome 5) for heaviness of cannabis use were approaching genome-wide significance. Both these SNPs were nominally significant (p<0.05) within males and females, however sex did not modify the association. The PRS identified statistically significant association with cannabis cravings. The variance explained by all PRSs were less than 1.02x10(-2). ConclusionThis study provides promising results in understanding the genetic contribution to cannabis use in individuals living with OUD.
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页数:14
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