β-C(sp3) -H chlorination of amide derivatives via photoinduced copper charge transfer catalysis

被引：9
|
作者：
He, Yuhang [1 ]
Tian, Chao [1 ]
An, Guanghui [1 ]
Li, Guangming [1 ]
机构：
[1] Heilongjiang Univ, Sch Chem & Mat Sci, Key Lab Funct Inorgan Mat Chem, MOE, Harbin 150080, Peoples R China
来源：
CHINESE CHEMICAL LETTERS | 2024年 / 35卷 / 02期
关键词：
Photoinduced copper catalysis; Ligand-to-metal charge transfer; 1,4-Hydrogen atom transfer; beta-Halogenated amide; Late-stage functionalization; PD(II)-CATALYZED BROMINATION; AMINO-ACIDS; FLUORINATION; KETONES; BONDS; IODINATION; CU2O;
D O I：
10.1016/j.cclet.2023.108546
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An atom economic beta-C(sp(3))-H chlorination of amide derivatives has been developed. This mild protocol employs CuCl2 instead of palladium catalysts with atom-economic HCl as chlorine sources and enables the late-stage functionalization of medicine derivatives. Mechanism studies suggest a plausible visible light triggered ligand-to-metal charge transfer (LMCT)/1,4-hydrogen atom transfer (HAT) cascade.
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页数：5
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