Hypervalent Iodine-Mediated Alkyne Functionalization: Facile Access to Trifluoromethyl- and Pentafluoroethyl-Substituted Thiazoles

被引：0
|
作者：
Kwak, Yoonna [1 ]
Choi, Ye Rin [1 ]
Yu, Jaeni [2 ]
Choi, Sungwook [2 ]
Hong, Ki Bum [1 ]
机构：
[1] Daegu Gyeongbuk Med Innovat Fdn KMEDIhub, New Drug Dev Ctr NDDC, 80 Cheombok Ro, Daegu, South Korea
[2] Chungnam Natl Univ, Dept New Drug Discovery & Dev, Daejon, South Korea
来源：
ASIAN JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 12卷 / 11期
基金：
新加坡国家研究基金会;
关键词：
thiazole synthesis; copper catalysis; thio-trifluoromethylation; thio-pentafluoroethylation; alkyne difunctionalization; FLUORINE; LACTONES; ACIDS;
D O I：
10.1002/ajoc.202300235
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
The use of hypervalent iodine with Lewis acid provided alkyne trifluoromethylation and pentafluoroethylation to access trifluoro-and pentafluoro-substituted thiazoles. This simple and efficient method is compatible with a broad range of aryl- and alkyl-substituted thiourea starting materials. Additionally, a gram-scale reaction proves the practicality of this transformation. The use of hypervalent iodine with Lewis acid provided alkyne trifluoromethylation and pentafluoroethylation to access trifluoro-and pentafluoro-substituted thiazoles.image
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页数：5
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