Transcription factor-mediated programming of stem cell fate

被引：4
|
作者：
Zhao, Yun [1 ]
Wang, Xi [2 ]
Wang, Kai [1 ,2 ,3 ,4 ]
机构：
[1] Peking Univ, Sch Basic Med Sci, Dept Physiol & Pathophysiol, State Key Lab Vasc Homeostasis & Remodeling, Beijing 100191, Peoples R China
[2] Peking Univ Third Hosp, Clin Stem Cell Res Ctr, Beijing 100191, Peoples R China
[3] Beijing Key Lab Metab Disorder Related Cardiovasc, Beijing 100050, Peoples R China
[4] Fuwai Hosp, State Key Lab Cardiovasc Dis, Beijing 100037, Peoples R China
来源：
TRENDS IN CELL BIOLOGY | 2023年 / 33卷 / 08期
基金：
国家重点研发计划;
关键词：
EXPRESSION;
D O I：
10.1016/j.tcb.2023.05.004
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Direct activation of transcription factors (TFs) in human pluripotent stem cells (hPSCs) allows more rapid and efficient conversion of cell fates compared with classical approaches. Here, we summarize recent TF screening studies and established forward programming methods for different cell types, and highlight their current limitations and future perspectives.
引用
收藏
页码：621 / 624
页数：4
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