The hippocampus undergoes maturation during juvenility, a period of increased vulnerability to environmental challenges. We recently found that acute high-fat diet (HFD) impaired hippocampal long-term potentiation (LTP) and hippocampal-dependent spatial memory. We also recently reported that similar HFD exposure affected prefrontal plasticity and social memory through decreased oxytocin levels in the prefrontal cortex. In the present study, we therefore evaluated whether hippocampal oxytocin levels are also affected by juvenile HFD and could mediate deficits of hippocampal LTP and spatial memory. We found that postweaning HFD decreased oxytocin levels in the CA1 of the dorsal hippocampus. Interestingly, systemic injection of high, but not low, dose of oxytocin rescued HFD-induced LTP impairment in CA1. Moreover, deficits in long-term object location memory (OLM) were prevented by systemic injection of both high and low dose of oxytocin as well as by intra-CA1 infusion of oxytocin receptor agonist. Finally, we found that blocking oxytocin receptors in CA1 impaired long-term OLM in control-fed juvenile rats. These results suggest that acute HFD intake lowers oxytocin levels in the CA1 that lead to CA1 plasticity impairment and spatial memory deficits in juveniles. Further, these results provide the first evidence for the regulatory role of oxytocin in spatial memory.
机构:
Univ Haifa, Sagol Dept Neurobiol, Fac Nat Sci, IL-3498838 Haifa, IsraelUniv Haifa, Sagol Dept Neurobiol, Fac Nat Sci, IL-3498838 Haifa, Israel
Yaseen, Aseel
Shrivastava, Kuldeep
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Univ Haifa, Sagol Dept Neurobiol, Fac Nat Sci, IL-3498838 Haifa, IsraelUniv Haifa, Sagol Dept Neurobiol, Fac Nat Sci, IL-3498838 Haifa, Israel
Shrivastava, Kuldeep
Zuri, Zohar
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Univ Haifa, Sagol Dept Neurobiol, Fac Nat Sci, IL-3498838 Haifa, IsraelUniv Haifa, Sagol Dept Neurobiol, Fac Nat Sci, IL-3498838 Haifa, Israel
Zuri, Zohar
Hatoum, Ossama A.
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Technion Israel Inst Technol, HaEmek Med Ctr Afula, Dept Surg B, IL-3525433 Haifa, Israel
Technion Israel Inst Technol, Fac Med, IL-3525433 Haifa, IsraelUniv Haifa, Sagol Dept Neurobiol, Fac Nat Sci, IL-3498838 Haifa, Israel
Hatoum, Ossama A.
Maroun, Mouna
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Univ Haifa, Sagol Dept Neurobiol, Fac Nat Sci, IL-3498838 Haifa, IsraelUniv Haifa, Sagol Dept Neurobiol, Fac Nat Sci, IL-3498838 Haifa, Israel
机构:
Univ Haifa, Fac Nat Sci, Sagol Dept Neurobiol, IL-3498838 Haifa, IsraelUniv Haifa, Fac Nat Sci, Sagol Dept Neurobiol, IL-3498838 Haifa, Israel
Khazen, Tala
Hatoum, Ossama A.
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Technion Israel Inst Technol, Dept Surg B, Fac Med, HaEmek Med Ctr, Haifa, IsraelUniv Haifa, Fac Nat Sci, Sagol Dept Neurobiol, IL-3498838 Haifa, Israel
Hatoum, Ossama A.
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Ferreira, Guillaume
Maroun, Mouna
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Univ Haifa, Fac Nat Sci, Sagol Dept Neurobiol, IL-3498838 Haifa, IsraelUniv Haifa, Fac Nat Sci, Sagol Dept Neurobiol, IL-3498838 Haifa, Israel
机构:
Univ Paulista UNIP, Grad Program Environm & Expt Pathol, Sao Paulo, SP, BrazilUniv Paulista UNIP, Grad Program Environm & Expt Pathol, Sao Paulo, SP, Brazil
Cardoso, C. V.
Otton, R.
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Univ Cruzeiro Sul, Grad Program Hlth Sci, Sao Paulo, SP, BrazilUniv Paulista UNIP, Grad Program Environm & Expt Pathol, Sao Paulo, SP, Brazil
Otton, R.
Martins, M. F.
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Univ Cruzeiro Sul, Dept Vet Med, Sao Paulo, SP, BrazilUniv Paulista UNIP, Grad Program Environm & Expt Pathol, Sao Paulo, SP, Brazil
Martins, M. F.
Bondan, E.
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Univ Paulista UNIP, Grad Program Environm & Expt Pathol, Sao Paulo, SP, Brazil
Univ Cruzeiro Sul, Dept Vet Med, Sao Paulo, SP, BrazilUniv Paulista UNIP, Grad Program Environm & Expt Pathol, Sao Paulo, SP, Brazil
机构:
Wenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Di, Affiliated Hosp 1, Wenzhou 325000, Peoples R ChinaWenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Di, Affiliated Hosp 1, Wenzhou 325000, Peoples R China
Lin, Cheng
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Lin, YanYan
Luo, Ji
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Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 1, Wenzhou 325000, Peoples R ChinaWenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Di, Affiliated Hosp 1, Wenzhou 325000, Peoples R China
Luo, Ji
Yu, JunRu
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Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 1, Wenzhou 325000, Peoples R China
Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 3, Wenzhou, Peoples R ChinaWenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Di, Affiliated Hosp 1, Wenzhou 325000, Peoples R China
Yu, JunRu
Cheng, YaNi
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Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 1, Wenzhou 325000, Peoples R ChinaWenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Di, Affiliated Hosp 1, Wenzhou 325000, Peoples R China
Cheng, YaNi
Wu, XiaoYun
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Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 1, Wenzhou 325000, Peoples R ChinaWenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Di, Affiliated Hosp 1, Wenzhou 325000, Peoples R China
Wu, XiaoYun
Lin, Lin
论文数: 0引用数: 0
h-index: 0
机构:
Wenzhou Hosp Tradit Chinese Med, Dept Gynecol & Obstet, Wenzhou, Peoples R ChinaWenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Di, Affiliated Hosp 1, Wenzhou 325000, Peoples R China
Lin, Lin
Lin, YuanShao
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Wenzhou Med Univ, Dept Neurol, Affiliated Hosp 1, Wenzhou 325000, Peoples R ChinaWenzhou Med Univ, Key Lab Diag & Treatment Severe Hepatopancreat Di, Affiliated Hosp 1, Wenzhou 325000, Peoples R China
机构:
Hamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, Iran
Islamic Azad Univ, Sci & Res Branch, Dept Biol, Tehran, IranHamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, Iran
Asadbegi, Masoumeh
Komaki, Alireza
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Hamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, IranHamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, Iran
Komaki, Alireza
Salehi, Iraj
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Hamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, IranHamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, Iran
Salehi, Iraj
Yaghmaei, Parichehreh
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Islamic Azad Univ, Sci & Res Branch, Dept Biol, Tehran, IranHamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, Iran
Yaghmaei, Parichehreh
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Ebrahim-Habibi, Azadeh
Shahidi, Siamak
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机构:
Hamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, IranHamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, Iran
Shahidi, Siamak
Sarihi, Abdolrahman
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Hamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, IranHamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, Iran
Sarihi, Abdolrahman
Asl, Sara Soleimani
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Hamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, IranHamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, Iran
Asl, Sara Soleimani
Golipoor, Zoleikha
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Hamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, IranHamadan Univ Med Sci, Neurophysiol Res Ctr, Hamadan, Iran