Hippocampal oxytocin is involved in spatial memory and synaptic plasticity deficits following acute high-fat diet intake in juvenile rats

被引:6
|
作者
Khazen, Tala [1 ,2 ]
Narattil, Nisha Rajan [1 ,2 ]
Ferreira, Guillaume [3 ]
Maroun, Mouna [1 ,2 ]
机构
[1] Univ Haifa, Sagol Dept Neurobiol, Fac Nat Sci, IL-3498838 Haifa, Israel
[2] Univ Haifa, Integrated Brain & Behav Res Ctr IBBRC, IL-3498838 Haifa, Israel
[3] Univ Bordeaux, INRAE, Nutr & Integrat Neurobiol, UMR 1286, F-3076 Bordeaux, France
关键词
hippocampus; juvenile; high-fat diet; oxytocin; LTP; RECEPTOR-BINDING; FOOD-INTAKE; VASOPRESSIN; BRAIN; STRESS; TRANSMISSION; EXPRESSION; AMYGDALA; RELEASE; NEURONS;
D O I
10.1093/cercor/bhac317
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
The hippocampus undergoes maturation during juvenility, a period of increased vulnerability to environmental challenges. We recently found that acute high-fat diet (HFD) impaired hippocampal long-term potentiation (LTP) and hippocampal-dependent spatial memory. We also recently reported that similar HFD exposure affected prefrontal plasticity and social memory through decreased oxytocin levels in the prefrontal cortex. In the present study, we therefore evaluated whether hippocampal oxytocin levels are also affected by juvenile HFD and could mediate deficits of hippocampal LTP and spatial memory. We found that postweaning HFD decreased oxytocin levels in the CA1 of the dorsal hippocampus. Interestingly, systemic injection of high, but not low, dose of oxytocin rescued HFD-induced LTP impairment in CA1. Moreover, deficits in long-term object location memory (OLM) were prevented by systemic injection of both high and low dose of oxytocin as well as by intra-CA1 infusion of oxytocin receptor agonist. Finally, we found that blocking oxytocin receptors in CA1 impaired long-term OLM in control-fed juvenile rats. These results suggest that acute HFD intake lowers oxytocin levels in the CA1 that lead to CA1 plasticity impairment and spatial memory deficits in juveniles. Further, these results provide the first evidence for the regulatory role of oxytocin in spatial memory.
引用
收藏
页码:3934 / 3943
页数:10
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