Relationship between brain iron dynamics and blood-brain barrier function during childhood: a quantitative magnetic resonance imaging study

被引:13
|
作者
Uchida, Yuto [1 ,2 ]
Kan, Hirohito [3 ]
Furukawa, Gen [4 ]
Onda, Kengo [1 ]
Sakurai, Keita [5 ]
Takada, Koji [6 ]
Matsukawa, Noriyuki [2 ]
Oishi, Kenichi [1 ,7 ]
机构
[1] Johns Hopkins Univ, Sch Med, Dept Radiol & Radiol Sci, 208 Traylor Bldg,720 Rutland Ave, Baltimore, MD 21205 USA
[2] Nagoya City Univ, Grad Sch Med Sci, Dept Neurol, 1,Kawasumi,Mizuho Cho,Mizuho Ku, Nagoya, Aichi 4678601, Japan
[3] Nagoya Univ, Grad Sch Med, Dept Integrated Hlth Sci, 1-1-20,Daiko Minami,Higashi Ku, Nagoya, Aichi 4618673, Japan
[4] Fujita Hlth Univ, Sch Med, Dept Pediat, 1-98,Kutsukake Cho,Dengakugakubo, Toyoake, Aichi 4701192, Japan
[5] Natl Ctr Geriatr & Gerontol, Dept Radiol, Morioka Cho, Obu, Aichi 4748511, Japan
[6] Toyokawa City Hosp, Dept Neurol, 23,Noji,Yawata Cho, Toyokawa, Aichi 4420857, Japan
[7] Richman Family Precis Med Ctr Excellence Alzheime, Baltimore, MD 21224 USA
基金
日本学术振兴会;
关键词
Blood-brain barrier; Diffusion-prepared pseudo-continuous arterial spin labeling; Magnetic resonance imaging; Pediatric brain; Quantitative susceptibility mapping; INTRACEREBRAL HEMORRHAGE; SUSCEPTIBILITY; TISSUE; PERFUSION; QUANTIFICATION; TRANSPORT; CHILDREN; EDEMA; TIMES; MRI;
D O I
10.1186/s12987-023-00464-x
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
BackgroundMounting evidence suggests that the blood-brain barrier (BBB) plays an important role in the regulation of brain iron homeostasis in normal brain development, but these imaging profiles remain to be elucidated. We aimed to establish a relationship between brain iron dynamics and BBB function during childhood using a combined quantitative magnetic resonance imaging (MRI) to depict both physiological systems along developmental trajectories.MethodsIn this single-center prospective study, consecutive outpatients, 2-180 months of age, who underwent brain MRI (3.0-T scanner; Ingenia; Philips) between January 2020 and January 2021, were included. Children with histories of preterm birth or birth defects, abnormalities on MRI, and diagnoses that included neurological diseases during follow-up examinations through December 2022 were excluded. In addition to clinical MRI, quantitative susceptibility mapping (QSM; iron deposition measure) and diffusion-prepared pseudo-continuous arterial spin labeling (DP-pCASL; BBB function measure) were acquired. Atlas-based analyses for QSM and DP-pCASL were performed to investigate developmental trajectories of regional brain iron deposition and BBB function and their relationships.ResultsA total of 78 children (mean age, 73.8 months & PLUSMN; 61.5 [SD]; 43 boys) were evaluated. Rapid magnetic susceptibility progression in the brain (& UDelta;susceptibility value) was observed during the first two years (globus pallidus, 1.26 & PLUSMN; 0.18 [x 10(- 3) ppm/month]; substantia nigra, 0.68 & PLUSMN; 0.16; thalamus, 0.15 & PLUSMN; 0.04). The scattergram between the & UDelta;susceptibility value and the water exchange rate across the BBB (k(w)) divided by the cerebral blood flow was well fitted to the sigmoidal curve model, whose inflection point differed among each deep gray-matter nucleus (globus pallidus, 2.96-3.03 [mL/100 g](-1); substantia nigra, 3.12-3.15; thalamus, 3.64-3.67) in accordance with the regional heterogeneity of brain iron accumulation.ConclusionsThe combined quantitative MRI study of QSM and DP-pCASL for pediatric brains demonstrated the relationship between brain iron dynamics and BBB function during childhood.
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页数:11
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