Long non-coding RNAs and gastric cancer: An update of potential biomarkers and therapeutic applications

被引：11
|
作者：
Hosseini, Sayedeh Azimeh [1 ,2 ,3 ]
Haddadi, Mohammad Hossein [4 ,11 ]
Fathizadeh, Hadis [5 ,6 ]
Nemati, Foroogh [7 ]
Aznaveh, Hooman Mahmoudi [8 ]
Taraj, Farima [9 ]
Aghabozorgizadeh, AmirArsalan [10 ]
Gandomkar, Golmaryam [9 ]
Bazazzadeh, Elaheh [8 ]
机构：
[1] Shahrekord Univ Med Sci, Sch Adv Technol, Dept Med Biotechnol, Shahrekord, Iran
[2] Shahrekord Univ Med Sci, Student Res Comm, Shahrekord, Iran
[3] Shahrekord Univ Med Sci, USERN Off, Shahrekord, Iran
[4] Ilam Univ Med Sci, Clin Microbiol Res Ctr, Ilam, Iran
[5] Sirjan Sch Med Sci, Student Res Comm, Sirjan, Iran
[6] Sirjan Sch Med Sci, Dept Lab Sci, Sirjan, Iran
[7] Kashan Univ Med Sci, Dept Microbiol, Kashan, Iran
[8] Tarbiat Modares Univ, Fac Biol Sci, Dept Nanobiotechnol, POB 14115-154, Tehran, Iran
[9] ACECR, Royan Inst Biotechnol, Cell Sci Res Ctr, Dept Anim Biotechnol, Esfahan, Iran
[10] Univ Isfahan, Fac Sci & Technol, Dept Cell & Mol Biol & Microbiol, Esfahan, Iran
[11] Ilam Univ Med Sci, Clin Microbiol Res Ctr CMRC, POB 6939177143, Ilam, Iran
来源：
BIOMEDICINE & PHARMACOTHERAPY | 2023年 / 163卷
关键词：
Long non-coding RNA; Gastric cancer; Molecular mechanisms; Diagnostic; Cancer treatment; Clinical relevance; EPITHELIAL-MESENCHYMAL-TRANSITION; PROMOTES CISPLATIN RESISTANCE; EXOSOME-MEDIATED TRANSFER; CELL-PROLIFERATION; INHIBITS APOPTOSIS; NONINVASIVE BIOMARKER; HELICOBACTER-PYLORI; LNCRNA SNHG5; INVASION; MALAT1;
D O I：
10.1016/j.biopha.2023.114407
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
The frequent metastasis of gastric cancer (GC) complicates the cure and therefore the development of effective diagnostic and therapeutic approaches is urgently necessary. In recent years, lncRNA has emerged as a drug target in the treatment of GC, particularly in the areas of cancer immunity, cancer metabolism, and cancer metastasis. This has led to the demonstration of the importance of these RNAs as prognostic, diagnostic and therapeutic agents. In this review, we provide an overview of the biological activities of lncRNAs in GC devel-opment and update the latest pathological activities, prognostic and diagnostic strategies, and therapeutic op-tions for GC-related lncRNAs.
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收藏
页数：24
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