Recent Advances of Basophils in Pruritic Skin Diseases

被引：0

作者：

Liu, Wenhui ^{[1
]}

Xu, Rui ^{[1
]}

Wang, Fang ^{[1
,2
]}

机构：

[1] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Dermatol, Guangzhou, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Dermatol, 58 Zhongshan Er Rd, Guangzhou 510080, Peoples R China

来源：

JOURNAL OF INVESTIGATIVE DERMATOLOGY | 2023年 / 143卷 / 05期

基金：

中国国家自然科学基金;

关键词：

ACTIVATION MARKERS; ALLERGIC INFLAMMATION; HISTAMINE-RELEASE; IGE; EXPRESSION; CELL; PATHOGENESIS; RESPONSES; TSLP; ITCH;

D O I：

10.1016/j.jid.2022.12.005

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Basophils are a rare type of granulocyte in peripheral blood. Owing to their accessibility in circulation and similarities to mast cells, basophils were considered a tool to gain insight into the function of mast cells. However, recent studies have uncovered that basophils have unique biology, specifically in activation, recruitment, and potential biomarkers. Accordingly, some previously unrecognized functions, particularly in neuroimmunology, have been found, suggesting a role of basophils in inflammatory and pruritic disorders. In this review, we aim to present an overview of basophil biology to show how basophils contribute to certain pruritic skin diseases.

引用

页码：691 / 698

页数：8

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