A Highly Selective Ratiometric Fluorescent Probe for the Detection of Hypochlorite in Acute Lung Injury

被引：1

作者：

Ding Binghui ^{[1
]}

Han Shaohui ^{[1
]}

Xiong Haiqing ^{[1
]}

Wang Benhua ^{[1
]}

Zuo Bojun ^{[2
]}

Song Xiangzhi ^{[1
]}

机构：

[1] Cent South Univ, Coll Chem Chem Engn, Changsha 410083, Peoples R China

[2] Shandong Acad Pesticide Sci, Jinan 250033, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2023年 / 43卷 / 08期

基金：

中国国家自然科学基金;

关键词：

acute lung injury; hypochlorous acid; fluorescent probe; ratiometric measurement; ACID; HCLO; HOCL;

D O I：

10.6023/cjoc202301003

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The fluorescent probe for the detection of overexpressed ClO- in acute lung injury is required to have high selectivity against other reactive species. A hydroxybenzo[g]coumarin, NaphCou, was synthesized as a ratiometric fluorescent probe to detect ClO- with ultra-high selectivity, a fast response, long-wavelength emissions (from green to red) and large Stokes shifts (from 107 nm to 155 nm). Using probe NaphCou as a fluorescence sensing tool, the lipopolysaccharide (LPS)-induced acute lung injury in mouse model was investigated by monitoring the hypochlorous acid concentration variation.

引用

页码：2878 / 2884

页数：7

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