Genetic diversity of Mycobacterium leprae in the state of S?o Paulo, an area of low-leprosy incidence in Brazil

被引：2
|
作者：
Finardi, Amanda Juliane [1 ,2 ]
de Oliveira, Nathan Guilherme [1 ,2 ]
de Moraes, Eloise Brasil [1 ,2 ]
Batista, Lavinia Cassia Ferreira [1 ,2 ]
Bortolomai, Bruna Eduarda [1 ,2 ]
Suffys, Philip Noel [3 ]
Baptista, Ida Maria Foschiani Dias [1 ,2 ]
机构：
[1] Inst Lauro Souza Lima, Bauru, SP, Brazil
[2] Univ Estadual Paulista, Fac Med, Botucatu, SP, Brazil
[3] Fundacao Oswaldo Cruz, Lab Biol Mol Aplicada Micobacterias, Rio De Janeiro, RJ, Brazil
来源：
REVISTA DA SOCIEDADE BRASILEIRA DE MEDICINA TROPICAL | 2023年 / 56卷
关键词：
Leprosy; Transmission; Mycobacterium leprae; Genetic Diversity; Geographic Information System; MOLECULAR EPIDEMIOLOGY; GENOTYPES; IDENTIFICATION; REGIONS; CEBU;
D O I：
10.1590/0037-8682-0612-2022
中图分类号：
R38 [医学寄生虫学]; Q [生物科学];
学科分类号：
07 ; 0710 ; 09 ; 100103 ;
摘要：
Background: Brazil has the second largest number of leprosy cases worldwide, and the state of Sao Paulo has been considered non -endemic since 2006.Methods: We analyzed 16 variable number tandem repeats loci and three single nucleotide polymorphisms loci of Mycobacterium leprae (M. leprae) in 125 clinical isolates from patients in different municipalities in the state.Results: The clustering pattern of M. leprae indicated that the transmission of leprosy persisted in the state and included scenarios of intra-extra-familial transmission in areas with low endemicity.Conclusions: A significantly active circulation of M. leprae was observed. Therefore, surveillance and control measures must be implemented.
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页数：5
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