X-ray phase contrast tomography with an immuno-histochemical approach

被引：0

作者：

Sanna, A. ^{[1
,2
,3
]}

Quarta, A. ^{[1
]}

Palermo, F. ^{[1
,2
]}

Pieroni, N. ^{[2
]}

Massimi, L.

Bravin, A. ^{[4
,5
]}

Sancey, L. ^{[3
]}

Cedola, A. ^{[1
,2
]}

机构：

[1] CNR Inst Nanotechnol, Lecce Unit Lecce, Lecce, Italy

[2] CNR Inst Nanotechnol, Rome Unit Rome, Rome, Italy

[3] Univ Grenoble Alpes, Inst Adv Biosci, INSERM U 1209, CNRS 5309, F-38000 Grenoble, France

[4] Univ Milano Bicocca, Dept Phys G Occhialini Milano, Milan, Italy

[5] Univ Calabria, Dept Phys Arcavacata Rende, Cosenza, Italy

来源：

NUOVO CIMENTO C-COLLOQUIA AND COMMUNICATIONS IN PHYSICS | 2023年 / 46卷 / 05期

关键词：

SPINAL-CORD; AGENTS;

D O I：

10.1393/ncc/i2023-23160-4

中图分类号：

O4 [物理学];

学科分类号：

0702 ;

摘要：

In the study of neurodegenerative diseases, a crucial point is the possibility of monitoring cells and tissues of interest within the body and tracking their modifications during the course of the disease or treatment. Currently, it is not possible to achieve this goal in-vivo, due to unsatisfactory image resolution, while conventional postmortem analysis necessitates the use of sample-destructive techniques. In this work, we propose to exploit the special characteristics of nanoparticles and nanobodies to enrich the abilities of nano and micro-XPCT, an innovative technique already used in the study of neurodegenerative disorders, and enhance it to tissue-selective 3D imaging, in addition to the morphological information provided by the 3D tomography.

引用

页数：4

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