Alkylamides from Acmella oleracea: antinociceptive effect and molecular docking with cannabinoid and TRPV1 receptors

被引：9
|
作者：
Kao Yien, Raissa M. [1 ]
Gomes, Anne Caroline C. [2 ]
Fiorot, Rodolfo Goetze [3 ]
Palhares Miranda, Ana Luisa [1 ]
Neves, Gilda A. [4 ]
Andrade, Brenda da Silva [4 ]
Costa, Fernanda N. [5 ]
Mendonca Tributino, Jorge Luiz [4 ]
Simas, Naomi Kato [1 ]
机构：
[1] Univ Fed Rio de Janeiro, Fac Farm, Programa Posgrad Ciencias Farmaceut, Rio De Janeiro, Brazil
[2] Inst Fed Educ Ciencia & Tecnol Rio de Janeiro, Campus Realengo, Rio De Janeiro, Brazil
[3] Univ Fed Fluminense, Inst Quim, Dept Quim Organ, Niteroi, RJ, Brazil
[4] Univ Fed Rio de Janeiro, Inst Ciencias Biomed, Rio De Janeiro, Brazil
[5] Univ Fed Rio de Janeiro, Inst Pesquisa Prod Nat Walter Mors IPPN, Rio De Janeiro, Brazil
来源：
NATURAL PRODUCT RESEARCH | 2023年 / 37卷 / 18期
关键词：
jambu; spilanthol; alkamides; cannabimimetics; R; K; JANSEN; FLOWERS; ISOBUTYLAMIDES; ACTIVATION; CAPSAICIN; ECHINACEA; LIGANDS; EXTRACT; MICE; CB2;
D O I：
10.1080/14786419.2022.2142221
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
Alkylamides are secondary metabolites in Acmella oleracea and display wide applications in treating several diseases. Since alkylamides can inhibit pain, this work aims to evaluate the antinociceptive profile of A. Oleracea methanolic extracts used in vivo and in silico assays. The extracts inhibited the neurogenic and inflammatory phases of the formalin test, ratifying the antinociceptive effect of alkylamides. Furthermore, the results from molecular docking demonstrated the interaction of A. oleracea alkylamides with the CB1/CB2 and TRPV1 receptors. Additionally, the crude methanolic extract of flowers did not induce potential side effects related to the classical cannabinoid tetrad: hypolocomotion and catalepsy. In conclusion, this work confirms the potential of the alkylamides of A. Oleracea as antinociceptive agents and, for the first time, correlates its effects with the endocannabinoid and vanilloid systems through in silico assays.
引用
收藏
页码：3136 / 3144
页数：9
相关论文
共 50 条
  • [1] Antinociceptive effect of natural and synthetic alkamides involves TRPV1 receptors
    de la Rosa-Lugo, Vianey
    Acevedo-Quiroz, Macdiel
    Deciga-Campos, Myrna
    Yolanda Rios, Maria
    [J]. JOURNAL OF PHARMACY AND PHARMACOLOGY, 2017, 69 (07) : 884 - 895
  • [2] The role of TRPV1 receptors in the antinociceptive effect of anandamide at spinal level
    Horvath, Gyoengyi
    Kekesi, Gabriella
    Nagy, Edit
    Benedek, Gyoergy
    [J]. PAIN, 2008, 134 (03) : 277 - 284
  • [3] Antiallodynic effect of PhAR-DBH-Me involves cannabinoid and TRPV1 receptors
    Nallely Quinonez-Bastidas, Geovanna
    Palomino-Hernandez, Oscar
    Lopez-Ortiz, Manuel
    Isaac Rocha-Gonzalez, Hector
    Melisa Gonzalez-Anduaga, Gloria
    Regla, Ignacio
    Navarrete, Andres
    [J]. PHARMACOLOGY RESEARCH & PERSPECTIVES, 2020, 8 (05):
  • [4] Distinct mechanisms underlying local antinociceptive and pronociceptive effects of natural alkylamides from Acmella oleracea compared to synthetic isobutylalkyl amide
    Dallazen, Jorge Luiz
    Maria-Ferreira, Daniele
    da Luz, Bruna Barbosa
    Nascimento, Adamara Machado
    Cipriani, Thales Ricardo
    de Souza, Lauro Mera
    Glugoski, Leticia Polli
    Goncalves Silva, Bruno Jose
    Geppetti, Pierangelo
    de Paula Werner, Maria Fernanda
    [J]. FITOTERAPIA, 2018, 131 : 225 - 235
  • [5] The Role of Cannabinoid Receptors and TRPV1 Channel in the Infarct-Reducing Effect of Cold Adaptation
    Naryzhnaya, Natalia
    Voronkov, Nikita
    Tsibulnikov, Sergey
    Maslov, Leonid
    [J]. FASEB JOURNAL, 2021, 35
  • [6] ROLE OF CANNABINOID AND TRPV1 RECEPTORS IN THE SPINAL MECHANISMS OF MICTURITION IN THE NORMAL RAT
    Campeau, Lysanne
    Fuellhase, Claudius
    Hedlund, Petter
    Howlett, Allyn
    Andersson, Karl-Erik
    [J]. JOURNAL OF UROLOGY, 2013, 189 (04): : E223 - E223
  • [7] Antinociceptive Effects of Cardamonin in Mice: Possible Involvement of TRPV1, Glutamate, and Opioid Receptors
    Ping, Chung Pui
    Mohamad, Tengku Azam Shah Tengku
    Akhtar, Muhammad Nadeem
    Perimal, Enoch Kumar
    Akira, Ahmad
    Ali, Daud Ahmad Israf
    Sulaiman, Mohd Roslan
    [J]. MOLECULES, 2018, 23 (09):
  • [8] Structural insights into TRPV1 from homology modeling, docking, and mutational studies for the discovery of TRPV1 modulators
    Lee, Jin Hee
    Lee, Yoonji
    Lee, Jeewoo
    Blumberg, Peter M.
    Choi, Sun
    [J]. ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2011, 241
  • [9] ANANDAMIDE - A DUAL PLAYER AT SPINAL CANNABINOID CB1 AND VANILLOID TRPV1 RECEPTORS
    Starowicz, K.
    Makuch, W.
    Petrosino, S.
    Di Marzo, V.
    Przewlocka, B.
    [J]. NEUROPEPTIDES, 2010, 44 (06) : 522 - 523
  • [10] TRPV1 Mediates The Orofacial Antinociceptive Effect of Frutalin: In Vivo and In Silico Studies
    Campos Barros, Adriana Rolim
    Mamede Vidal Damasceno, Marina de Barros
    Alves Rodrigues Santos, Sacha Aubrey
    de Albuquerque Melo Junior, Jose de Maria
    Alves Magalhaes, Francisco Ernani
    Vieira-Neto, Antonio Eufrasio
    Moreira, Renato de Azevedo
    de Oliveria Monteiro-Moreira, Ana Cristina
    [J]. FASEB JOURNAL, 2017, 31
12345