Structure-Activity Relationships Guided Engineering of AAV Capsids with Optimized Skeletal Muscle, Cardiac Muscle, and CNS Tropism

被引：0

作者：

Olivieri, Kevin ^{[1
]}

Tan, Jie ^{[1
]}

Huang, Lin-Ya ^{[1
]}

Lee, Jackson ^{[1
]}

Malyszka, Stephanie ^{[1
]}

Siripurapu, Sri ^{[1
]}

Fieldsend, Allegra ^{[2
]}

Pryce, Cynthia ^{[1
]}

Edwards, Matt ^{[1
]}

Mastis, Bryan ^{[1
]}

Calcedo, Roberto ^{[1
]}

Richman, Laura K. ^{[3
]}

Cao, Sherry ^{[1
]}

Albright, Charles F. ^{[1
]}

机构：

[1] Affinia Therapeut, Waltham, MA USA

[2] Affinia Therapeut Inc, Waltham, MA USA

[3] Affinia Theraput, Damascus, MD USA

来源：

MOLECULAR THERAPY | 2023年 / 31卷 / 04期

关键词：

D O I：

暂无

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

102

引用

页码：55 / 56

页数：2

共 34 条

[1] Discovery and Characterization of Novel AAV Capsids with Enhanced Skeletal Muscle Tropism Using Directed Evolution
Palla, Adelaida
Jin, Quan
Heusey, Haley
Li, Frank
Tran, Jimmy
Kumar, Amit
Bodnar, Dora
Hinckley, Chris
Hung, Ka Ying
Kashyap, Samneet
Diallo, Aissatou
Rouse, Emily
Kelemen, Margaret
Xiang, Lucia
Utturkar, Aditya
Chittoda, Misha
Sampath, Harini Dhamodaran
Bourque, Shawn Kyle
Desmarais, Samantha
Henry, Kate
Deng, Shuyun
Chen, Wei Tong
Gianni, Davide
Shi, Jun
Suh, Junghae
Yuan, Yuan
MOLECULAR THERAPY, 2024, 32 (04) : 767 - 767
[2] Discovery of Novel AAV Capsids with Enhanced Skeletal Muscle Tropism Following Directed Evolution in Cynomolgus Macaque
Jin, Quan
Hung, Ka Ying Sharon
Kashyap, Samneet
Rouse, Emily
Kelemen, Margaret
Xiang, Lucia
Utturkar, Aditya
Chittoda, Misha
Sampath, Harini
Bourque, Shawn
Desmarais, Samantha
Deng, Shuyun
Chen, Wei Tong
Gianni, Davide
Suh, Junghae
Yuan, Yuan
MOLECULAR THERAPY, 2023, 31 (04) : 556 - 556
[3] BATRACHOTOXIN ANALOGS ON CARDIAC-MUSCLE - STRUCTURE-ACTIVITY RELATIONSHIPS
SHOTZBER.GS
ALBUQUER.EX
DALY, J
WITKOP, B
PHARMACOLOGIST, 1973, 15 (02): : 233 - 233
[4] Engineered AAV capsids with significantly improved muscle and CNS tropism plus reduced liver and DRG expression compared to AAV9
Olivieri, K.
Tan, J.
Huang, L.
Lee, J.
Malyszka, S.
Siripurapu, S.
Fieldsend, A.
Pryce, C.
Edwards, T. M.
Mastis, B.
Calcedo, R.
Richman, L.
Cao, S.
Albright, C.
Reece-Hoyes, J. S.
HUMAN GENE THERAPY, 2024, 35 (3-4) : A75 - A75
[5] STRUCTURE-ACTIVITY STUDIES ON NIFEDIPINE IN ISOLATED CARDIAC-MUSCLE
RODENKIRCHEN, R
BAYER, R
STEINER, R
BOSSERT, F
MEYER, H
MOLLER, E
NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 1979, 310 (01) : 69 - 78
[6] STRUCTURE-ACTIVITY RELATIONSHIP FOR GRAYANOTOXIN DERIVATIVES IN FROG SKELETAL-MUSCLE
MASUTANI, T
SEYAMA, I
NARAHASHI, T
IWASA, J
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 1981, 217 (03): : 812 - 819
[7] ADENOSINE ANALOGS - STRUCTURE-ACTIVITY RELATIONSHIPS IN VASCULAR AND INTESTINAL SMOOTH-MUSCLE
LESLIE, SW
BOROWITZ, JL
MIYA, TS
JOURNAL OF PHARMACEUTICAL SCIENCES, 1973, 62 (09) : 1449 - 1452
[8] Structure-Activity Relationships of Polyphenols To Prevent Lipid Oxidation in Pelagic Fish Muscle
Pazos, Manuel
Iglesias, Jacobo
Maestre, Rodrigo
Medina, Isabel
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2010, 58 (20) : 11067 - 11074
[9] Effects of flavonoids on rat aortic smooth muscle contractility: Structure-activity relationships
Herrera, MD
Zarzuelo, A
Jimenez, J
Marhuenda, E
Duarte, J
GENERAL PHARMACOLOGY-THE VASCULAR SYSTEM, 1996, 27 (02): : 273 - 277
[10] STRUCTURE ACTIVITY RELATIONSHIPS IN A SERIES OF SEMISYNTHETIC ESTERS OF PROTOVERINE IN SKELETAL-MUSCLE
GUJRAL, PK
INDIAN JOURNAL OF MEDICAL RESEARCH, 1975, 63 (03) : 437 - 443

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