Bleomycin electrosclerotherapy (BEST) for the treatment of vascular malformations. An International Network for Sharing Practices on Electrochemotherapy (InspECT) study group report

被引：12

作者：

Muir, Tobian ^{[1
]}

Bertino, Giulia ^{[2
]}

Groselj, Ales ^{[3
,4
]}

Ratnam, Lakshmi ^{[5
]}

Kis, Erika ^{[6
]}

Odili, Joy ^{[7
]}

McCafferty, Ian ^{[8
]}

Wohlgemuth, Walter A. ^{[9
]}

Cemazar, Maja ^{[10
,11
]}

Krt, Aljosa ^{[11
]}

Bosnjak, Masa ^{[10
]}

Zanasi, Alessandro ^{[12
]}

Battista, Michela ^{[12
]}

de Terlizzi, Francesca ^{[12
]}

Campana, Luca G. ^{[13
]}

Sersa, Gregor ^{[10
,14
]}

机构：

[1] James Cook Univ Hosp, Dept Reconstruct Plast Surg, Middlesbrough, England

[2] Univ Pavia, Ist Ricovero & Cura Carattere Sci IRCCS Policlin S, Dept Otolaryngol Head Neck Surg, Pavia, Italy

[3] Univ Med Ctr Ljubljana, Dept Otorhinolaryngol & Cervicofacial Surg, Ljubljana, Slovenia

[4] Univ Ljubljana, Fac Med, Ljubljana, Slovenia

[5] St Georges Univ Hosp NHS Fdn Trust, Dept Intervent Radiol, London, England

[6] Univ Szeged, Dept Dermatol & Allergol, Szeged, Hungary

[7] St Georges Univ Hosp NHS Trust, Dept Plast Surg, London, England

[8] Birmingham Womens & Childrens Hosp NHS Fdn Trust, Birmingham, England

[9] Univ Med Halle, Univ Klin & Poliklin Radiol, Halle, Germany

[10] Inst Oncol Ljubljana, Dept Expt Oncol, Zaloska 2, SI-1000 Ljubljana, Slovenia

[11] Univ Primorska, Fac Hlth Sci, Koper, Slovenia

[12] IGEA SpA, Clin Biophys Lab Carpi, Carpi, Modena, Italy

[13] Manchester Univ NHS Fdn Trust, Dept Surg, Manchester, England

[14] Univ Ljubljana, Fac Hlth Sci, Ljubljana, Slovenia

来源：

RADIOLOGY AND ONCOLOGY | 2023年 / 57卷 / 02期

关键词：

vascular malformations; bleomycin electrosclerotherapy; bleomycin; electrochemotherapy; ELECTROPORATION; HEAD; POTENTIATION; MANAGEMENT; TUMORS; NECK;

D O I：

10.2478/raon-2023-0029

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Biomedical applications of electroporation are expanding out of the field of oncology into vaccination, treatment of arrhythmias and now in the treatment of vascular malformations. Bleomycin is a widely used sclerosing agent in the treatment of various vascular malformations. The application of electric pulses in addition to bleomycin enhances the effectiveness of the drug, as demonstrated by electrochemotherapy, which utilizes bleomycin in the treatment of tumors. The same principle is used in bleomycin electrosclerotherapy (BEST). The approach seems to be effective in the treatment of low-flow (venous and lymphatic) and, potentially, even high-flow (arteriovenous) malformations. Although there are only a few published reports to date, the surgical community is interested, and an increasing number of centers are applying BEST in the treatment of vascular malformations. Within the International Network for Sharing Practices on Electrochemotherapy (InspECT) consortium, a dedicated working group has been constituted to develop standard operating procedures for BEST and foster clinical trials.Conclusions: By treatment standardization and successful completion of clinical trials demonstrating the effectiveness and safety of the approach, higher quality data and better clinical outcomes may be achieved.

引用

页码：141 / 149

页数：9

共 10 条

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